{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:42:07Z","timestamp":1773758527588,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2016]]},"abstract":"Background<\/jats:italic>. Our aim was to define the conditions that affect therapeutic success when dipeptidyl peptidase-4 (DPP-4) inhibitor is added to metformin monotherapy.Materials and Methods<\/jats:italic>. We reviewed the medical records of 56 patients who had received DPP-4 inhibitor as an add-on to metformin monotherapy and evaluated their response in the first year of therapy. Fasting blood glucose (FBG), HbA1c, C-peptide, and weight of the patients were recorded at 3-month intervals during the first year of treatment.Results<\/jats:italic>. Patients who added DPP-4 inhibitor to metformin monotherapy had significant weight loss (P<\/mml:mi>=<\/mml:mo>0.004<\/mml:mn><\/mml:math>) and FBG and HbA1c levels were significantly lowered during the first 6 months (bothP<\/mml:mi><<\/mml:mo>0.001<\/mml:mn><\/mml:math>). Baseline levels of C-peptide were predictive for success of the treatment (P<\/mml:mi>=<\/mml:mo>0.02<\/mml:mn><\/mml:math>), even after correction for confounding factors, for example, age, gender, or BMI (P<\/mml:mi>=<\/mml:mo>0.03<\/mml:mn><\/mml:math>). Duration of diabetes was not a predictor of response to treatment (P<\/mml:mi>=<\/mml:mo>0.60<\/mml:mn><\/mml:math>).Conclusion<\/jats:italic>. Our study demonstrates that in patients having inadequate glycemic control, the addition of a DPP-4 inhibitor as a second oral agent to metformin monotherapy provides better glycemic control, protects\u03b2<\/jats:italic>-cell reserves, and does not cause weight gain. These effects depend on baseline C-peptide levels.<\/jats:p>","DOI":"10.1155\/2016\/4509603","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T17:00:48Z","timestamp":1478106048000},"page":"1-4","source":"Crossref","is-referenced-by-count":6,"title":["C-Peptide Levels Predict the Effectiveness of Dipeptidyl Peptidase-4 Inhibitor Therapy"],"prefix":"10.1155","volume":"2016","author":[{"given":"Sevin","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Eleskirt Public Hospital, 04600 Agri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0450-755X","authenticated-orcid":true,"given":"Sule","family":"Temizkan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, Kartal Dr. Lutfi Kirdar Training and Research Hospital, 34890 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Sargin","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Medeniyet University Goztepe Training and Research Hospital, 34722 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","first-page":"386","volume":"27","year":"2007","journal-title":"Turkiye Klinikleri Journal of Medical Sciences"},{"key":"2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5835\/jecm.omu.29.s1.007","volume":"29","year":"2012","journal-title":"Journal of Experimental and Clinical Medicine"},{"key":"3","first-page":"45","volume":"6","year":"2012","journal-title":"Turkish Journal of Family Medicine & Primary Care"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3899-2"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2011.00184.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.2007.3.2.203"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2174\/1874104501105010082"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-012-0008-5"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1135"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2460"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2006.00691.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01417.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03764.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1932"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2011.0278"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.6.881"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2016\/4509603.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2016\/4509603.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2016\/4509603.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T22:39:48Z","timestamp":1498343988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jdr\/2016\/4509603\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":16,"alternative-id":["4509603","4509603"],"URL":"https:\/\/doi.org\/10.1155\/2016\/4509603","relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}