{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T01:40:38Z","timestamp":1776908438258,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401755"],"award-info":[{"award-number":["81401755"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"Knowing the biological age of the neonates enables us to evaluate and better understand the health and maturity comprehensively. However, because of dearth of biomarkers, it is difficult to quantify the neonatal biological age. Here we sought to quantify and assess the variability in biological age at birth and to better understand how the aging rates before birth are influenced by exposure in intrauterine period by employing a novel epigenetic biomarker of aging (epigenetic clock). We observed that the methylation age at birth was independent of the infant\u2019s sex but was significantly influenced by race. Partial correlation analysis showed a significant negative relationship between maternal socioeconomic status and infants\u2019 methylation age (r<\/mml:mi><\/mml:mrow>s<\/mml:mi><\/mml:mrow><\/mml:msub>=<\/mml:mo>-<\/mml:mo>0.48<\/mml:mn><\/mml:math>, P<\/mml:mi><\/mml:mrow>s<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math> = 0.005). A significant association with the risk of fast aging was observed for prenatal exposure to tobacco smoke with OR (95% CI) of 3.17 (1.05\u20139.56). Both estimated cell abundance measures and lymphocyte subpopulations in cord blood showed that tobacco exposed group exhibit an altered T cell compartment, specifically substantial loss of naive T cells. Present study provides the first evidence that common perinatal exposure (such as maternal smoking and lower socioeconomic status) may be important aging accelerators and substantial loss of naive T cells may play a role in the smoking-related fast aging phenomenon.<\/jats:p>","DOI":"10.1155\/2016\/4515928","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T18:20:18Z","timestamp":1481566818000},"page":"1-10","source":"Crossref","is-referenced-by-count":43,"title":["Infant\u2019s DNA Methylation Age at Birth and Epigenetic Aging Accelerators"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7914-7811","authenticated-orcid":true,"given":"Ruheena","family":"Javed","sequence":"first","affiliation":[{"name":"Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Jinsui Road 9, Tianhe District, Guangzhou, Guangdong 510623, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Jinsui Road 9, Tianhe District, Guangzhou, Guangdong 510623, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangqin","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Jinsui Road 9, Tianhe District, Guangzhou, Guangdong 510623, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9987-8002","authenticated-orcid":true,"given":"Huiying","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Jinsui Road 9, Tianhe District, Guangzhou, 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