{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:56:07Z","timestamp":1740164167156,"version":"3.37.3"},"reference-count":7,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Q fever is a zoonotic bacterial disease caused by<jats:italic>Coxiella burnetii<\/jats:italic>. Tumor necrosis factor-alpha (TNF-<jats:italic>\u03b1<\/jats:italic>) plays a pivotal role in the defense against infection with this Gram-negative coccobacillus. Theoretically, patients who are treated with anti-TNF-<jats:italic>\u03b1<\/jats:italic>medications are at risk for developing chronic Q fever. We present two patients who developed Q fever while being treated with anti-TNF-<jats:italic>\u03b1<\/jats:italic>agents and discuss the significance of timely diagnosis of<jats:italic>C. burnetii<\/jats:italic>infection in these patients.<\/jats:p>","DOI":"10.1155\/2016\/4586150","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T17:58:00Z","timestamp":1472579880000},"page":"1-3","source":"Crossref","is-referenced-by-count":3,"title":["Q Fever Risk in Patients Treated with Chronic Antitumor Necrosis Factor-Alpha Therapy"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2911-2113","authenticated-orcid":true,"given":"Julianna","family":"Hirsch","sequence":"first","affiliation":[{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Astrahan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine A, Bnai Zion Medical Center, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majed","family":"Odeh","sequence":"additional","affiliation":[{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion, Haifa, Israel"},{"name":"Department of Internal Medicine A, Bnai Zion Medical Center, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizar","family":"Elias","sequence":"additional","affiliation":[{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion, Haifa, Israel"},{"name":"Department of Internal Medicine A, Bnai Zion Medical Center, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itzhak","family":"Rosner","sequence":"additional","affiliation":[{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion, Haifa, Israel"},{"name":"Department of Rheumatology, Bnai Zion Medical Center, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doron","family":"Rimar","sequence":"additional","affiliation":[{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion, Haifa, Israel"},{"name":"Department of Rheumatology, Bnai Zion Medical Center, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Kaly","sequence":"additional","affiliation":[{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion, Haifa, Israel"},{"name":"Department of Rheumatology, Bnai Zion Medical Center, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rozenbaum","sequence":"additional","affiliation":[{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion, Haifa, Israel"},{"name":"Department of Rheumatology, Bnai Zion Medical Center, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Boulman","sequence":"additional","affiliation":[{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion, Haifa, Israel"},{"name":"Department of Rheumatology, Bnai Zion Medical Center, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gleb","family":"Slobodin","sequence":"additional","affiliation":[{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion, Haifa, Israel"},{"name":"Department of Rheumatology, Bnai Zion Medical Center, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.04.024"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12073"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1128\/iai.01767-06"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205455"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2015.09.002"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-330"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146819"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2016\/4586150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2016\/4586150.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2016\/4586150.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T17:58:01Z","timestamp":1472579881000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criid\/2016\/4586150\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":7,"alternative-id":["4586150","4586150"],"URL":"https:\/\/doi.org\/10.1155\/2016\/4586150","relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"type":"print","value":"2090-6625"},{"type":"electronic","value":"2090-6633"}],"subject":[],"published":{"date-parts":[[2016]]}}}