{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T22:38:33Z","timestamp":1778193513048,"version":"3.51.4"},"reference-count":35,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>Cystic fibrosis-associated liver disease (CFLD) is a major cause of death. The objective of our retrospective study was to describe the relevance of magnetic resonance imaging (MRI) and liver stiffness measurement (LSM) for CFLD evaluation.<jats:italic>Methods.<\/jats:italic>All cystic fibrosis adult patients evaluated by MRI and LSM were included. MR signs of portal hypertension (PHT), dysmorphia, or cholangitis were collected and LSM expressed in kPa and Metavir.<jats:italic>Results.<\/jats:italic>Of 25 patients, 52% had abnormal MRI. Median LSM was 5.7\u2009kPa (3.4\u20139.9). Three patients had F2 score and one had F3 score. In patients with PHT, LSM was 7.85\u2009kPa (3.7\u20139.9) compared to 5 (3.4\u20137.5) in others,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.02<\/mml:mn><\/mml:math>. In patients with abnormal liver function tests, 50% had increased LSM (\u2265F2), whereas 94% with normal tests had normal LSM (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.04<\/mml:mn><\/mml:math>). Seven patients had abnormal MRI despite normal ultrasonography.<jats:italic>Conclusions.<\/jats:italic>MRI and LSM provide useful information on CFLD and may help to screen patients with PHT.<\/jats:p>","DOI":"10.1155\/2016\/4592702","type":"journal-article","created":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T09:16:57Z","timestamp":1467105417000},"page":"1-8","source":"Crossref","is-referenced-by-count":10,"title":["Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?"],"prefix":"10.1155","volume":"2016","author":[{"given":"C.","family":"Lemaitre","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dominique","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, 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