{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T19:41:29Z","timestamp":1769974889708,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>An 88-year-old man was diagnosed with trigeminal neuralgia, and treatment of carbamazepine 200\u2009mg\/day was initiated. About 6 weeks later, the patient developed a skin rash accompanied by fever. He was admitted to hospital and diagnosed with drug-induced hypersensitivity syndrome (DIHS) caused by carbamazepine. Oral carbamazepine treatment was stopped, but blood tests showed acute liver and acute renal failure. Drug-induced lymphocyte stimulation test (DLST) for carbamazepine, human herpes virus-6 (HHV-6) IgG, and CMV-HRP were negative. Oral prednisolone therapy was begun 18 days later. The titer of HHV-6 IgG antibodies was then detected (640 times). Following treatment, liver and renal function improved and the erythema disappeared.<\/jats:p>","DOI":"10.1155\/2016\/4605231","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T17:01:05Z","timestamp":1478192465000},"page":"1-4","source":"Crossref","is-referenced-by-count":2,"title":["Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia"],"prefix":"10.1155","volume":"2016","author":[{"given":"Yuko","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8525, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7811-2366","authenticated-orcid":true,"given":"Tsuyoshi","family":"Shimo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8525, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Shirafuji","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8525, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8525, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Masui","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8525, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoichi","family":"Obata","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8525, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8525, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8525, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8525, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.2.183"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2013.05.002"},{"issue":"2","key":"3","first-page":"347","volume":"52","year":"2009","journal-title":"Japan Medical Association Journal"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.1"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01176.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i44.4928"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq537"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1590\/s0365-05962012000300013"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08167.x"}],"container-title":["Case Reports in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crid\/2016\/4605231.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crid\/2016\/4605231.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crid\/2016\/4605231.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T17:01:06Z","timestamp":1478192466000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crid\/2016\/4605231\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":9,"alternative-id":["4605231","4605231"],"URL":"https:\/\/doi.org\/10.1155\/2016\/4605231","relation":{},"ISSN":["2090-6447","2090-6455"],"issn-type":[{"value":"2090-6447","type":"print"},{"value":"2090-6455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}