{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T06:07:28Z","timestamp":1772345248669,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pathogens"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Corynebacterium pseudotuberculosis<\/jats:italic>causes caseous lymphadenitis (CLA), which is a contagious and chronic disease in sheep and goats. In order to assess the histopathological changes observed in the reproductive organs of nonpregnant does infected with the bacteria, 20 apparently healthy adult Boer does were divided into four inoculation groups, intradermal, intranasal, oral, and control, consisting of five goats each. Excluding the control group, which was unexposed, other does were inoculated with 10<jats:sup>7<\/jats:sup>\u2009CFU\/1\u2009mL of live<jats:italic>C. pseudotuberculosis<\/jats:italic>through the various routes stated above<jats:italic>.<\/jats:italic>Thirty days after infection, the ovaries, uterus, and iliac lymph nodes were collected for bacterial recovery and molecular detection, as well as histopathological examination. The mean changes in necrosis, congestion, inflammatory cell infiltration, and oedema varied in severity among the ovaries, uterus, and iliac lymph nodes following different inoculation routes. Overall, the intranasal route of inoculation showed more severe (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) lesions in all the organs examined. The findings of this study have shown that<jats:italic>C. pseudotuberculosis<\/jats:italic>could predispose to infertility resulting from pathological lesions in the uterus and ovaries of does.<\/jats:p>","DOI":"10.1155\/2016\/4624509","type":"journal-article","created":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T21:01:50Z","timestamp":1456261310000},"page":"1-7","source":"Crossref","is-referenced-by-count":15,"title":["Reproductive Pathological Changes Associated with Experimental Subchronic<i>Corynebacterium pseudotuberculosis<\/i>Infection in Nonpregnant Boer Does"],"prefix":"10.1155","volume":"2016","author":[{"given":"A. M.","family":"Othman","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Abba","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia"},{"name":"Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, PMB 1069, Maiduguri 600233, Borno State, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. F. A.","family":"Jesse","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia"},{"name":"Research Centre for Ruminant Disease, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. M.","family":"Ilyasu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Saharee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia"},{"name":"Research Centre for Ruminant Disease, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W.","family":"Haron","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia"},{"name":"Research Centre for Ruminant Disease, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zamri-Saad","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A. M.","family":"Lila","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2007.12.025"},{"issue":"1","key":"18","first-page":"145","volume":"34","year":"2011","journal-title":"Pertanika Journal of Tropical Agricultural Science"},{"issue":"4","key":"14","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/ajcp\/76.4.486","volume":"76","year":"1981","journal-title":"American Journal of Clinical Pathology"},{"issue":"3","key":"23","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2460\/ajvr.1984.45.03.557","volume":"45","year":"1984","journal-title":"American Journal of Veterinary Research"},{"key":"10","first-page":"1387","volume-title":"Corynebacterium pseudotuberculosis infections","year":"1994"},{"issue":"2","key":"2","first-page":"73","volume":"17","year":"2013","journal-title":"Journal of Veterinary Research"},{"key":"22","first-page":"524","volume":"5","year":"2014","journal-title":"Journal of Veterinary Advances"},{"key":"27","first-page":"359","volume":"17","year":"2001","journal-title":"Veterinary Clinics of North America"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2003.tb11443.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-5877(03)00060-6"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2004014"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2005056"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2007.07.002"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-1135(02)00089-5"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-4320(96)01614-4"},{"key":"1","year":"1998"},{"key":"6","first-page":"99","volume-title":"The haematoxylin and eosin","volume":"4th","year":"1996"},{"key":"16","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.3382\/ps.0591006","volume":"59","year":"1980","journal-title":"Poultry Science"},{"key":"15","first-page":"63","volume":"12","year":"2000","journal-title":"Journal of Veterinary Malaysia"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.9790\/2380-0132429"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700510204"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/bf01568281"},{"issue":"6","key":"5","doi-asserted-by":"crossref","first-page":"874","DOI":"10.2460\/ajvr.1990.51.06.874","volume":"51","year":"1990","journal-title":"American Journal of Veterinary Research"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/271246a0"},{"key":"29","first-page":"1103","volume-title":"Female reproductive system and mammary gland","year":"2013"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3844\/ajavsp.2015.112.132"},{"key":"26","first-page":"238","volume-title":"Caseous lymphadenitis","volume":"3","year":"1993"},{"issue":"4","key":"19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1590\/1808-1657v73p3952006","volume":"73","year":"2006","journal-title":"Arquivos do Instituto Biol\u00f3gico"}],"container-title":["Journal of Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpath\/2016\/4624509.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpath\/2016\/4624509.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpath\/2016\/4624509.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T13:51:00Z","timestamp":1748785860000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jpath\/2016\/4624509\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":28,"alternative-id":["4624509","4624509"],"URL":"https:\/\/doi.org\/10.1155\/2016\/4624509","relation":{},"ISSN":["2090-3057","2090-3065"],"issn-type":[{"value":"2090-3057","type":"print"},{"value":"2090-3065","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}