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Eggs produced by normally developed female worms are important in the transmission of the parasite, and they responsible for the pathogenesis of schistosomiasis. The tumor suppressor gene<jats:italic>lethal giant larvae (lgl)<\/jats:italic>has an essential function in establishing apical-basal cell polarity, cell proliferation, differentiation, and tissue organization. In our earlier study, downregulation of the<jats:italic>lgl<\/jats:italic>gene induced a significant reduction in the egg hatching rate of<jats:italic>Schistosoma japonicum (Sj)<\/jats:italic>eggs. 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