{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:25:57Z","timestamp":1791653157111,"version":"4.3.4"},"reference-count":101,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T00:00:00Z","timestamp":1461715200000},"content-version":"vor","delay-in-days":117,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EURope Against Infant Brain Injury Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Oxidative stress is a distinctive sign in several genetic disorders characterized by cancer predisposition, such as Ataxia\u2010Telangiectasia, Fanconi Anemia, Down syndrome, progeroid syndromes, Beckwith\u2010Wiedemann syndrome, and Costello syndrome. Recent literature unveiled new molecular mechanisms linking oxidative stress to the pathogenesis of these conditions, with particular regard to mitochondrial dysfunction. Since mitochondria are one of the major sites of ROS production as well as one of the major targets of their action, this dysfunction is thought to be the cause of the prooxidant status. Deeper insight of the pathogenesis of the syndromes raises the possibility to identify new possible therapeutic targets. In particular, the use of mitochondrial\u2010targeted agents seems to be an appropriate clinical strategy in order to improve the quality of life and the life span of the patients.<\/jats:p>","DOI":"10.1155\/2016\/4782426","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T23:09:32Z","timestamp":1461798572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Oxidative Stress in Cancer\u2010Prone Genetic Diseases in Pediatric Age: The Role of Mitochondrial Dysfunction"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5478-5657","authenticated-orcid":false,"given":"Serafina","family":"Perrone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0395-7524","authenticated-orcid":false,"given":"Federica","family":"Lotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7500-8686","authenticated-orcid":false,"given":"Ursula","family":"Geronzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0878-5346","authenticated-orcid":false,"given":"Elisa","family":"Guidoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Longini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Buonocore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,27]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90279-7"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92211-X"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2012.13659"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2013_1944"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj20061131"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-3163-5-14"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/11.3.298"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2003.11.001"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000049134.69131.89"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.12.009"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers2020859"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2004.09.007"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.00307-08"},{"key":"e_1_2_9_14_2","first-page":"1","article-title":"Inflammation and oxidative stress in carcinogenesis","volume":"3","author":"Cerutti P. A.","year":"1991","journal-title":"Cancer Cells"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2010.03.007"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0531-5565(84)90029-9"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.002"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2004.04.020"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.39.110304.095751"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.001"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/541230"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-010-9269-4"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox5010007"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.2174\/157489212799972891"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.05.003"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.123.3191.309"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2013.00292"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-007-9403-0"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.03.002"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060722"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986711803414368"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000443994"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.184"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520180210"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520320119"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40569-5"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/14.10.2131"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007638025856"},{"key":"e_1_2_9_39_2","first-page":"1","article-title":"Ataxia-telangiectasia: an overview","volume":"19","author":"Boder E.","year":"1985","journal-title":"Kroc Foundation Series"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.1999.550501.x"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.4137\/CMO.S535"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-10-200011210-00009"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1011"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.04.020"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1159\/000056900"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1089\/15230860260196254"},{"key":"e_1_2_9_47_2","first-page":"204","article-title":"Antioxidant enzymes in red blood cells and lymphocytes of ataxia-telangiectasia patients","volume":"46","author":"Aksoy Y.","year":"2004","journal-title":"Turkish Journal of Pediatrics"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi324"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/762048"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2011.10.002"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-456897"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.330"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm166"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.203"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2007.11.008"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2009.01.013"},{"key":"e_1_2_9_57_2","volume-title":"Gene Reviews","author":"Alter B. P.","year":"2013"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-102108-134222"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.195248.112"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-011-1098-y"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207256"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1977.tb01223.x"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC-2011-227"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2129"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-381970"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.583"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200607061"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-28"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702879"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/154279"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1448"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.07.011"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02027.x"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200102000-00007"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2006.10.019"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.12.010"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/724904"},{"key":"e_1_2_9_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.11.016"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.03.025"},{"key":"e_1_2_9_80_2","first-page":"5239","article-title":"Elevated superoxide dismutase in Bloom\u2019s syndrome: a genetic condition of oxidative stress","volume":"49","author":"Nicotera T. M.","year":"1989","journal-title":"Cancer Research"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.06.003"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.10.046"},{"key":"e_1_2_9_83_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl214"},{"key":"e_1_2_9_84_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100649"},{"key":"e_1_2_9_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.26.2989"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2007.00743.x"},{"key":"e_1_2_9_87_2","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.9.2.10379"},{"key":"e_1_2_9_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.171"},{"key":"e_1_2_9_89_2","first-page":"691","article-title":"Antioxidant effects of potassium ascorbate with ribose in costello syndrome","volume":"33","author":"Anichini C.","year":"2013","journal-title":"Anticancer Research"},{"key":"e_1_2_9_90_2","first-page":"3973","article-title":"Beckwith-Wiedemann syndrome: potassium ascorbate with ribose therapy in a syndrome with high neoplastic risk","volume":"31","author":"Anichini C.","year":"2011","journal-title":"Anticancer Research"},{"key":"e_1_2_9_91_2","doi-asserted-by":"publisher","DOI":"10.1177\/147323000903700634"},{"key":"e_1_2_9_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.02.012"},{"key":"e_1_2_9_93_2","first-page":"249","article-title":"Pharmacological ascorbic acid suppresses syngeneic tumor growth and metastases in hormone-refractory prostate cancer","volume":"24","author":"Pollard H. B.","year":"2010","journal-title":"In Vivo"},{"key":"e_1_2_9_94_2","first-page":"29","article-title":"Mitochondria, energy and cancer: the relationship with ascorbic acid","volume":"25","author":"Gonz\u00e1lez M. J.","year":"2010","journal-title":"The Journal of Orthomolecular Medicine"},{"key":"e_1_2_9_95_2","doi-asserted-by":"publisher","DOI":"10.3233\/DMA-2012-0922"},{"key":"e_1_2_9_96_2","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12083"},{"key":"e_1_2_9_97_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00034711"},{"key":"e_1_2_9_98_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.10.753"},{"key":"e_1_2_9_99_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.11218"},{"key":"e_1_2_9_100_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20567"},{"key":"e_1_2_9_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.104"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2016\/4782426.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2016\/4782426.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/4782426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:40:42Z","timestamp":1722908442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/4782426"}},"subtitle":[],"editor":[{"given":"Gabriele","family":"Saretzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":101,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/4782426"],"URL":"https:\/\/doi.org\/10.1155\/2016\/4782426","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2016-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4782426"}}