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We aimed to explore the effects of SM on oxidative stress in aging\u2010associated CVDs. Through literature searches using Medicine, PubMed, EMBASE, Cochrane library, CINAHL, and Scopus databases, we found that SM not only possesses antioxidant, antiapoptotic, and anti\u2010inflammatory effects but also exerts angiogenic and cardioprotective activities. SM may reduce the production of reactive oxygen species by inhibiting oxidases, reducing the production of superoxide, inhibiting the oxidative modification of low\u2010density lipoproteins, and ameliorating mitochondrial oxidative stress. SM also increases the activities of catalase, manganese superoxide dismutase, glutathione peroxidase, and coupled endothelial nitric oxide synthase. In addition, SM reduces the impact of ischemia\/reperfusion injury, prevents cardiac fibrosis after myocardial infarction, preserves cardiac function in coronary disease, maintains the integrity of the blood\u2010brain barrier, and promotes self\u2010renewal and proliferation of neural stem\/progenitor cells in stroke. However, future clinical well\u2010designed and randomized control trials will be necessary to confirm the efficacy of SM in aging\u2010associated CVDs.<\/jats:p>","DOI":"10.1155\/2016\/4797102","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T21:20:35Z","timestamp":1476220835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Oxidative Stress and <i>Salvia miltiorrhiza<\/i> in Aging\u2010Associated Cardiovascular Diseases"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9553-8342","authenticated-orcid":false,"given":"Cheng-Chieh","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9549-6202","authenticated-orcid":false,"given":"Wen-Long","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7490-4465","authenticated-orcid":false,"given":"Yu-Chiang","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,11]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gheart.2014.03.1220"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008720"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.717033"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112054"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(76)80402-4"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90061-8"},{"key":"e_1_2_8_8_2","first-page":"438","article-title":"Community surveillance for cerebrovascular disease: the Framingham Cardiovascular Disease Survey","volume":"93","author":"Gillum R. 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