{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:03:15Z","timestamp":1740164595740,"version":"3.37.3"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome characterized by excessive activation of the immune system. Bacterial infections are very rare precipitants of this disease. A 19-year-old gentleman presented with headache, fatigue, and malaise. He was found to be hypotensive, tachycardic, and febrile. Broad spectrum antibiotics were initiated, and a lumbar puncture ruled out meningitis. Patient progressively developed shock that required use of vasopressors, as well as renal and respiratory failure. Blood cultures grew<jats:italic>Fusobacterium necrophorum<\/jats:italic>. Given continued fevers despite appropriate antimicrobials, a bone marrow biopsy was performed revealing increased histiocytes with hemophagocytosis. Dexamethasone was added with dramatic clinical improvement. Our case highlights<jats:italic>Fusobacterium<\/jats:italic>as a rare precipitant of HLH and proves that a high index of clinical suspicion is crucial for early diagnosis of HLH, allowing for prompt initiation of HLH-specific immunosuppressive therapy that can be life-saving.<\/jats:p>","DOI":"10.1155\/2016\/4839146","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T17:03:51Z","timestamp":1470243831000},"page":"1-2","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Cause of Hemophagocytic Lymphohistiocytosis:<i>Fusobacterium<\/i>Infection\u2014A Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6464-783X","authenticated-orcid":true,"given":"Ghulam Rehman","family":"Mohyuddin","sequence":"first","affiliation":[{"name":"Kansas University Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather J.","family":"Male","sequence":"additional","affiliation":[{"name":"Division of Hematologic Malignancies and Cellular Therapeutics (HMCT), Department of Internal Medicine, University of Kansas Cancer Center, 2330 Shawnee Mission Parkway, Mailstop 5003, Westwood, KS 66205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(13)61048-x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s0163-4453(98)94711-9"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-602607"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21423"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-356261"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.04.034"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0172"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-551622"},{"issue":"114","key":"10","volume":"1","year":"2013","journal-title":"Journal of Bone Marrow Research"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2011.1.178"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2016\/4839146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2016\/4839146.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2016\/4839146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T17:03:52Z","timestamp":1470243832000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crihem\/2016\/4839146\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":11,"alternative-id":["4839146","4839146"],"URL":"https:\/\/doi.org\/10.1155\/2016\/4839146","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2016]]}}}