{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T15:09:25Z","timestamp":1776179365904,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371147"],"award-info":[{"award-number":["81371147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Oral lichen planus (OLP) is a T cell-mediated inflammatory autoimmune disease. Autophagy has emerged as a fundamental trafficking event in mediating T cell response, which plays crucial roles in innate and adaptive immunity. The present study mainly investigated the mRNA expression of autophagy-associated genes in peripheral blood T cells of OLP patients and evaluated correlations between their expression and the clinical features of OLP. Five differentially expressed autophagy-associated genes were identified by autophagy array. Quantitative real-time RT-PCR results confirmed that<jats:italic>IGF1<\/jats:italic>expression in the peripheral blood T cells of OLP patients was significantly higher than that in controls, especially in female and middle-aged (30\u201350 years old) OLP patients. In addition,<jats:italic>ATG9B<\/jats:italic>mRNA levels were significantly lower in nonerosive OLP patients. However, no significant differences were found in the expression of<jats:italic>HGS<\/jats:italic>,<jats:italic>ESR1<\/jats:italic>, and<jats:italic>SNCA<\/jats:italic>between OLP patients and controls. Taken together, dysregulation of T cell autophagy may be involved in immune response of OLP and may be correlated with clinical patterns.<\/jats:p>","DOI":"10.1155\/2016\/4867368","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T16:01:44Z","timestamp":1455552104000},"page":"1-10","source":"Crossref","is-referenced-by-count":20,"title":["Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features"],"prefix":"10.1155","volume":"2016","author":[{"given":"Ya-Qin","family":"Tan","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"The State Key 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