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In this study, the effect of GRA on<jats:italic>Helicobacter pylori<\/jats:italic>- (<jats:italic>H. pylori<\/jats:italic>-) infected gastritis was investigated in Mongolian gerbils<jats:italic>in vivo<\/jats:italic>. The gerbils were randomly divided into groups: uninfected;<jats:italic>H. pylori<\/jats:italic>-infected;<jats:italic>H. pylori<\/jats:italic>+ antibiotics (clarithromycin, amoxicillin, and esomeprazole); and<jats:italic>H. pylori<\/jats:italic>+ GRA. The gastric intraluminal pH value, histopathological changes, and the expression levels of inflammation-related cytokines (IL-1<jats:italic>\u03b2<\/jats:italic>, TNF-<jats:italic>\u03b1<\/jats:italic>, COX-2, and iNOS) were investigated. The results showed that, in the<jats:italic>H. pylori<\/jats:italic>+ GRA group, the intraluminal gastric pH value was lower (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn fontstyle=\"italic\">2.14<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.08<\/mml:mn><\/mml:math>versus<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn fontstyle=\"italic\">3.17<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.23<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>), erosion and hyperplasia were alleviated, the infiltration of neutrophils and mononuclear cells was attenuated (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>), and the expression levels of TNF-<jats:italic>\u03b1<\/jats:italic>, IL-1<jats:italic>\u03b2<\/jats:italic>, COX-2, and iNOS were decreased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) compared with the<jats:italic>H. pylori<\/jats:italic>-infected group. There was no significant difference in results between the<jats:italic>H. pylori<\/jats:italic>+ GRA group and the<jats:italic>H. pylori<\/jats:italic>+ antibiotics group. This study indicated that GRA significantly attenuated<jats:italic>H. pylori<\/jats:italic>-infected gastritis in gerbils and has the potential to be developed as a new therapeutic drug.<\/jats:p>","DOI":"10.1155\/2016\/4943793","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T20:16:46Z","timestamp":1456345006000},"page":"1-8","source":"Crossref","is-referenced-by-count":28,"title":["The Protective Effects of 18<i>\u03b2<\/i>-Glycyrrhetinic Acid on<i>Helicobacter pylori<\/i>-Infected Gastric Mucosa in Mongolian Gerbils"],"prefix":"10.1155","volume":"2016","author":[{"given":"Donghui","family":"Cao","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 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