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IL-1<jats:italic>\u03b2<\/jats:italic>has been associated with tumor development and invasiveness in different types of cancer, including gastric cancer. Currently, it is not clear if there is an association between CagA and IL-1<jats:italic>\u03b2<\/jats:italic>at a cellular level. In this study, we analyzed the effects of IL-1<jats:italic>\u03b2<\/jats:italic>and CagA on MCF-10A nontransformed cells. We found evidence that both CagA and IL-1<jats:italic>\u03b2<\/jats:italic>trigger the initiation of the epithelial-to-mesenchymal transition characterized by<jats:italic>\u03b2<\/jats:italic>-catenin nuclear translocation, increased expression of<jats:italic>Snail1<\/jats:italic>and<jats:italic>ZEB1<\/jats:italic>, downregulation of<jats:italic>CDH1<\/jats:italic>, and morphological changes during MCF-10A acini formation. However, only CagA induced MMP9 activity and cell invasion. Our data support that IL-1<jats:italic>\u03b2<\/jats:italic>and CagA target the<jats:italic>\u03b2<\/jats:italic>-catenin pathway, with CagA leading to acquisition of a stage related to aggressive tumors.<\/jats:p>","DOI":"10.1155\/2016\/4969163","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T21:04:12Z","timestamp":1469048652000},"page":"1-10","source":"Crossref","is-referenced-by-count":1,"title":["<i>Helicobacter pylori<\/i>CagA and IL-1<i>\u03b2<\/i>Promote the Epithelial-to-Mesenchymal Transition in a Nontransformed Epithelial Cell Model"],"prefix":"10.1155","volume":"2016","author":[{"given":"Haruki","family":"Ar\u00e9valo-Romero","sequence":"first","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Avenida Instituto Polit\u00e9cnico Nacional 2508, San Pedro Zacatenco, 07360 Ciudad de M\u00e9xico, DF, Mexico"},{"name":"Unidad de 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