{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:24:07Z","timestamp":1778869447200,"version":"3.51.4"},"reference-count":25,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To investigate the changes in serum Myeloid-Related Protein 8\/14 (MRP8\/14) and Eosinophil Cationic Protein (ECP) levels in patients with different types of coronary artery diseases (CAD) and assess the value of MRP8\/14 and ECP detection in predicting CAD.<jats:italic>Methods<\/jats:italic>. 178 patients were divided into CAD group including unstable angina pectoris (UAP), acute myocardial infarction (AMI), and stable angina pectoris (SAP). Thirty-six individuals with normal coronary artery served as the control group. Serum MRP8\/14 and ECP were measured by ELISA. The severity of coronary artery stenosis was assessed by the numbers of involved coronary artery branches and the sum of Gensini scores.<jats:italic>Results<\/jats:italic>. The MRP8\/14 levels were significantly higher in AMI and UAP group than SAP and control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.0<\/mml:mn><mml:mn fontstyle=\"italic\">5<\/mml:mn><\/mml:math>). The levels of MRP8\/14 in AMI group were also obviously higher than UAP group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.0<\/mml:mn><mml:mn fontstyle=\"italic\">5<\/mml:mn><\/mml:math>). The ECP levels were obviously increased in AMI group, but there was no difference between SAP and UAP group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.0<\/mml:mn><mml:mn fontstyle=\"italic\">5<\/mml:mn><\/mml:math>). The ECP was significantly increased in three impaired coronary arteries and obviously correlated with Gensini score (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>), whereas the MRP8\/14 was obviously positively correlated with CRP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Increased MRP8\/14 levels suggest the instability of the atherosclerotic plaque. ECP reflects the severity of coronary arteries stenosis, predicting atherosclerosis burden. They may become the new biomarkers of CAD.<\/jats:p>","DOI":"10.1155\/2016\/4980251","type":"journal-article","created":{"date-parts":[[2016,2,28]],"date-time":"2016-02-28T16:01:05Z","timestamp":1456675265000},"page":"1-8","source":"Crossref","is-referenced-by-count":23,"title":["The Correlation of Serum Myeloid-Related Protein-8\/14 and Eosinophil Cationic Protein in Patients with Coronary Artery Disease"],"prefix":"10.1155","volume":"2016","author":[{"given":"Guo-lian","family":"Xia","sequence":"first","affiliation":[{"name":"The Affiliated Hospital of Zhejiang Traditional Chinese Medicine University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-kai","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Zhejiang Traditional Chinese Medicine University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-quan","family":"Huang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Zhejiang Traditional Chinese Medicine University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"5","key":"1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.5551\/jat.7591","volume":"18","year":"2011","journal-title":"Journal of Atherosclerosis and Thrombosis"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/jim.0000000000000095"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.814582"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2014.975358"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002974"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.15171\/bi.2014.006"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(83)80105-2"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-009-0054-4"},{"key":"9","first-page":"7","volume":"51","year":"1975","journal-title":"Circulation"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1373\/49.4.594"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.607333"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.11.036"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.000903"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/nm1638"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m509442200"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm078"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1177\/2048872614554107"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.109.190314"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-09-0564"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-10-0192"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-11-6"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp120"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.02.038"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.07.002"},{"issue":"3","key":"25","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.amjcard.2014.04.048","volume":"114","year":"2014","journal-title":"American Journal of Cardiology"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/4980251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/4980251.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/4980251.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T03:10:32Z","timestamp":1498273832000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2016\/4980251\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":25,"alternative-id":["4980251","4980251"],"URL":"https:\/\/doi.org\/10.1155\/2016\/4980251","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}