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The effects of oral administration of RNP<jats:sup>N<\/jats:sup>to APAP\u2010treated mice were assessed for various biochemical liver function parameters: alanine transaminase (ALT) activity, aspartate transaminase (AST) activity, alkaline phosphatase (ALP) activity, prothrombin time, and serum albumin (ALB) level. The treatment effects were assessed in terms of free radical parameters: malondialdehyde (MDA) accumulation, glutathione peroxidase (GPx) activity, % inhibition of superoxide anion (), and histopathological examination. The<jats:italic>N<\/jats:italic>\u2010acetylcysteine (NAC)\u2010treated group exhibited an enhanced prothrombin time relative to the control group, while RNP<jats:sup>N<\/jats:sup>did not prolong prothrombin time. The RNP<jats:sup>N<\/jats:sup>\u2010treated animals exhibited lower levels of ALT, AST, and ALP, while increased ALB levels were measured in these animals compared to those in the other groups. The RNP<jats:sup>N<\/jats:sup>\u2010treated animals furthermore exhibited improved MDA levels, GPx activity, and % inhibition of , which relate to oxidative damage. Histological staining of liver tissues from RNP<jats:sup>N<\/jats:sup>\u2010treated animals did not reveal any microscopic changes relative to the other groups. The findings of this study suggest that RNP<jats:sup>N<\/jats:sup>possesses effective hepatoprotective properties and does not exhibit the notable adverse effects associated with NAC treatment.<\/jats:p>","DOI":"10.1155\/2016\/4984597","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T21:02:43Z","timestamp":1458248563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Redox Nanoparticle Therapeutics for Acetaminophen\u2010Induced Hepatotoxicity in Mice"],"prefix":"10.1155","volume":"2016","author":[{"given":"Phetcharat","family":"Boonruamkaew","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pennapa","family":"Chonpathompikunlert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Nagasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1943-278X.2000.tb01098.x"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajem.2002.34955"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90758-0"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199710163371602"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-12-200212170-00007"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20293"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2005.00947.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21799"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.06.006"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2012.07.006"},{"key":"e_1_2_8_11_2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-3565(25)29666-5","article-title":"Acetaminophen induced hepatic necrosis. 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