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A total of 37 eyes of 20 patients\u2019 medical records were reviewed. Patients first received IVR (0.25\u2009mg\/0.025\u2009mL) and later photocoagulation. The mean postconceptual age of injection was 34.6 \u00b1 1.4 weeks, and the mean follow-up period was 39.3 \u00b1 8.3 weeks. During the follow-up, 96.6% eyes had various degree of rapid absorption of vitreous hemorrhage after IVR. The mean time of received first photocoagulation after IVR was 4.8 \u00b1 2.9 weeks. Ten (27.0%) eyes received second laser therapy and the mean time of second laser therapy after IVR was 3.2 \u00b1 0.8 weeks. All eyes exhibited adequate regression of ROP and were stable with attached retina. Fibrosis membrane was observed in seven eyes (18.9%) and three of them demonstrated mild ectopic macula. No significant side effects related to IVR were observed. So IVR could be conducted as primary treatment of AP-ROP associated with vitreous hemorrhage, which can improve the fundus visibility, followed by conventional photocoagulation. Further randomized controlled trials are necessary to compare the clinical efficacy and safety with conventional interventions.<\/jats:p>","DOI":"10.1155\/2016\/5029278","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T18:28:35Z","timestamp":1481740115000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["Combination of Intravitreal Injection of Ranibizumab and Photocoagulation for the Treatment of Aggressive Posterior Retinopathy of Prematurity with Vitreous Hemorrhage"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0574-1460","authenticated-orcid":true,"given":"Yu","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, 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