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However, little is known about its role in chronic spontaneous urticaria (CSU). We therefore investigated expression of IFN-<jats:italic>\u03bb<\/jats:italic>1 in CSU, its cellular location, and its influence on inflammatory cell accumulation by using flow cytometry analysis, skin tissue dispersion, immunohistochemical stain, and a mouse peritoneal inflammation model. The results showed that level of IFN-<jats:italic>\u03bb<\/jats:italic>1 was 2.0-fold higher in plasma of the patients with CSU than the level in healthy control (HC) subjects. Among leukocytes examined, only CD8<jats:sup>+<\/jats:sup>T cells expressed more IFN-<jats:italic>\u03bb<\/jats:italic>1 in CSU blood. Double labeling immunohistochemical staining revealed that IFN-<jats:italic>\u03bb<\/jats:italic>1<jats:sup>+<\/jats:sup>inflammatory cells such as mast cells, eosinophils, B cells, neutrophils, and macrophages were mainly located in dermis, whereas epidermis tissue highly expressed IFN-<jats:italic>\u03bb<\/jats:italic>1. IFN-<jats:italic>\u03bb<\/jats:italic>1 induced a dose-dependent increase in number of eosinophils, lymphocytes, mast cells, macrophages, and neutrophils in the peritoneum of mice at 6\u2009h following injection, which was inhibited by pretreatment of the animals with anti-intercellular adhesion molecule- (ICAM-) 1 and\/or anti-L-selectin antibodies. In conclusion, IFN-<jats:italic>\u03bb<\/jats:italic>1 is likely to play a role in the pathogenesis of CSU. Blocking IFN-<jats:italic>\u03bb<\/jats:italic>1 production may help to reduce the accumulation of inflammatory cells in the involved CSU skin.<\/jats:p>","DOI":"10.1155\/2016\/5032051","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T22:29:38Z","timestamp":1467325778000},"page":"1-13","source":"Crossref","is-referenced-by-count":7,"title":["Elevated Plasma Level of Interferon-<i>\u03bb<\/i>1 in Chronic Spontaneous Urticaria: Upregulated Expression in CD8<sup>+<\/sup>and Epithelial Cells and Induction of Inflammatory Cell Accumulation"],"prefix":"10.1155","volume":"2016","author":[{"given":"S. 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