{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:41:32Z","timestamp":1778024492804,"version":"3.51.4"},"reference-count":51,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Functional dyspepsia (FD) is a functional upper gastrointestinal disorder with significant morbidity and medical costs. Previous studies investigated the association of G-protein<jats:italic>\u03b2<\/jats:italic>3 (GNB3) genetic polymorphisms with FD but with inconsistent results. Therefore, we performed a meta-analysis to derive a precise estimation of the relationship between GNB3 polymorphisms and FD.<jats:italic>Methods<\/jats:italic>. We searched different databases including PubMed, EMBASE, CNKI, and the Ovid Library to gather eligible studies on GNB3 polymorphisms and FD. The association was assessed by the odds ratio (OR) with 95% confidence intervals (CI).<jats:italic>Results<\/jats:italic>. We identified 12 studies with 1109 cases and 2853 controls for the analysis. We found no associations of GNB3 C825T polymorphism with FD in the overall population (T versus C, OR = 1.06, 95% CI: 0.96\u20131.18,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.26<\/mml:mn><\/mml:math>; TT versus CC + CT, OR = 1.16, 95% CI: 0.97\u20131.39,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.11<\/mml:mn><\/mml:math>; TT + CT versus CC, OR = 1.01, 95% CI: 0.77\u20131.31,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.96<\/mml:mn><\/mml:math>; TT versus CC, OR = 1.15, 95% CI: 0.93\u20131.44,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.20<\/mml:mn><\/mml:math>). Subgroup analyses by genotyping method indicated that the magnitude of association was strengthened for additive model (OR = 1.15, 95% CI: 1.07\u20132.24,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.02<\/mml:mn><\/mml:math>). Sensitivity analysis did not reveal significant associations under all models.<jats:italic>Conclusions<\/jats:italic>. This meta-analysis demonstrates that GNB3 C825T polymorphism may not be a risk factor for FD.<\/jats:p>","DOI":"10.1155\/2016\/5037254","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T21:05:22Z","timestamp":1451595922000},"page":"1-11","source":"Crossref","is-referenced-by-count":10,"title":["The C825T Polymorphism of the G-Protein<i>\u03b2<\/i>3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis"],"prefix":"10.1155","volume":"2016","author":[{"given":"Yi-Zuo","family":"Song","sequence":"first","affiliation":[{"name":"Zhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He-Yi","family":"You","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe-Hui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-De","family":"Wen","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi-Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong-Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Ke","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated 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