{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:28:59Z","timestamp":1787236139265,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T00:00:00Z","timestamp":1463356800000},"content-version":"vor","delay-in-days":136,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173222"],"award-info":[{"award-number":["81173222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . The complementary and alternative medicines in treatment of diarrhea\u2010predominant irritable bowel syndrome (IBS\u2010D) are controversial.\n                    <jats:italic>Methods<\/jats:italic>\n                    . We searched PubMed, Ovid Embase, Web of Science, Cochrane Library databases, CNKI, Wanfang Database, CBM, VIP, and AMED for randomized controlled trials (RCTs) of moxibustion compared with pharmacological medications in patients with IBS\u2010D. A meta\u2010analysis was performed using both fixed and random\u2010effects models based on heterogeneity across studies.\n                    <jats:italic>Results<\/jats:italic>\n                    . In total, 568 patients in 7 randomized controlled trials were randomly treated with moxibustion and pharmacological medications. The improvement of global IBS\u2010D symptoms and overall scores was significant (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0001 and\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001, resp.) in patients treated by moxibustion only compared to pharmacological medications. The specific IBS\u2010D symptoms of abdominal pain, abdominal distension, abnormal stool, and defecation frequency were alleviated in patients treated by moxibustion compared to pharmacological medications, but no significance was found except for abdominal distension and defecation frequency (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.03 and\n                    <jats:italic>P<\/jats:italic>\n                    = 0.02, resp.). There were no serious adverse events related to moxibustion.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Moxibustion appears to be effective in treating IBS\u2010D compared with pharmacological medications. However, further large, rigorously designed trials are warranted due to insufficient methodological rigor in the included trials.\n                  <\/jats:p>","DOI":"10.1155\/2016\/5105108","type":"journal-article","created":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T17:01:28Z","timestamp":1463418088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Moxibustion for Diarrhea\u2010Predominant Irritable Bowel Syndrome: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1155","volume":"2016","author":[{"given":"Bozong","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongguo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingnian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,16]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.14309\/00000434-200901001-00002"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.07.005"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02463.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0b013e318189a7f9"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.07.008"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.t01-1-01736.x"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.2625"},{"key":"e_1_2_9_8_2","first-page":"393","article-title":"Prevalence of use of alternative and complementary medicine in patients with irritable bowel syndrome, functional dyspepsia and gastroesophageal reflux disease","volume":"70","author":"Carmona-S\u00e1nchez R.","year":"2005","journal-title":"Revista de gastroenterolog\u00eda de M\u00e9xico"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2010.12.005"},{"key":"e_1_2_9_10_2","first-page":"134","article-title":"Management of irritable bowel syndrome (IBS) in adults: conventional and complementary\/alternative approaches","volume":"16","author":"Yoon S. L.","year":"2011","journal-title":"Alternative Medicine Review"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1003-5257(12)60019-1"},{"key":"e_1_2_9_12_2","first-page":"19","article-title":"Clinical research on moxibustion treatment of diarrhea type irritable bowel syndrome","volume":"11","author":"Ni Y. Y.","year":"2001","journal-title":"World Journal of Acupuncture-Moxibustion"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-247"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1003-5257(12)60019-1"},{"key":"e_1_2_9_15_2","first-page":"39","article-title":"The curative effect observation and nursing of moxibustion combined with pinaverium bromide tablets to cure abdominal pain and diarrhea intestine irritable syndrome","volume":"15","author":"Luo S. J.","year":"2008","journal-title":"Journal of Jinggangshan Medical College"},{"key":"e_1_2_9_16_2","first-page":"69","article-title":"Thirty cases of diarrhea-predominant irritable bowel syndrome treated by ginger-partitioned moxibustion","volume":"38","author":"Zhang Y. B.","year":"2007","journal-title":"Jiangxi Journal of Traditional Chinese Medicine"},{"key":"e_1_2_9_17_2","first-page":"415","article-title":"The efficiency observation of tianjiu therapy on irritable bowel syndrome of diarrhea type","volume":"33","author":"Jin G. D.","year":"2009","journal-title":"Journal of Zhejiang College of Traditional Chinese Medicine"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11726-011-0528-y"},{"key":"e_1_2_9_19_2","first-page":"33","article-title":"Moxibustion for diarrhea-type irritable bowel syndrome: a clinical study","volume":"30","author":"Chu H.","year":"2011","journal-title":"Journal of Anhui TCM College"},{"key":"e_1_2_9_20_2","first-page":"199","article-title":"Thirty two cases of diarrhea-predominant irritable bowel syndrome treated by heat-sensitive moxibustion","volume":"48","author":"Chen S. X.","year":"2013","journal-title":"Zhejiang Journal of Traditional Chinese Medicine"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/605460"},{"key":"e_1_2_9_22_2","series-title":"Version 5.1.0","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins J. P. T.","year":"2011"},{"key":"e_1_2_9_23_2","volume-title":"Theory & Practice of Systematic Review\/Meta-Analysis","author":"Luo J.","year":"2013"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2005.03.001"},{"key":"e_1_2_9_26_2","first-page":"237","article-title":"Rome III: new standard for functional gastrointestinal disorders","volume":"15","author":"Drossman D. A.","year":"2006","journal-title":"Journal of Gastrointestinal and Liver Diseases"},{"key":"e_1_2_9_27_2","first-page":"169","article-title":"The epidemic survey of Fujian teenagers with irritable bowel syndrome","volume":"27","author":"Zhou S. Q.","year":"2007","journal-title":"Chinese Journal of Digestive Diseases"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014528151"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04656.x"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.4321\/s1130-01082013000100005"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2010.13507"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00937.x"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/920675"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i5.662"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673-5374.2011.33.007"},{"key":"e_1_2_9_37_2","first-page":"984","article-title":"Clinical study on 5-HT expression in colonic mucosa and the treatment of herb-partition moxibustion in diarrhea-predominant IBS","volume":"33","author":"Liu H. R.","year":"2006","journal-title":"Liaoning Zhongyi Zazhi"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9270(02)04270-3"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-247"},{"key":"e_1_2_9_40_2","first-page":"10","article-title":"Clinical study on spleen-stomach-reinforcing moxibustion treatment of diarrhea-type irritable bowel syndrome","volume":"12","author":"Wu H. G.","year":"2002","journal-title":"World Journal of Acupunct-Moxibust"},{"key":"e_1_2_9_41_2","first-page":"24","article-title":"Quality of life in managed care patients with irritable bowel syndrome","volume":"17","author":"Wilson A.","year":"2004","journal-title":"Managed Care Interface"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-009-9461-7"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/5105108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/5105108.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/5105108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T21:28:57Z","timestamp":1722893337000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/5105108"}},"subtitle":[],"editor":[{"given":"Jiande D. Z.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/5105108"],"URL":"https:\/\/doi.org\/10.1155\/2016\/5105108","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2015-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5105108"}}