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A novel composite endpoint of GVHD\u2010free\/relapse\u2010free survival (GRFS) in which events include grades 3\u20104 acute GVHD, chronic GVHD requiring systemic therapy, relapse, or death is censored to completely characterize the survival without mortality or ongoing morbidity. In this regard, studies attempting to identify the prognostic factors of GRFS are quite scarce. Thus, we reviewed 377 adult patients undergoing allogeneic HSCT between 2003 and 2013. The 1\u2010 and 2\u2010year GRFS were 40.8% and 36.5%, respectively, significantly worse than overall survival and disease\u2010free survival (log\u2010rank <jats:italic>p<\/jats:italic> &lt; 0.001). European Group for Blood and Marrow Transplantation (EBMT) risk score &gt; 2 (<jats:italic>p<\/jats:italic> &lt; 0.001) and hematologic malignancy (<jats:italic>p<\/jats:italic> = 0.033) were poor prognostic factors for 1\u2010year GRFS. For 2\u2010year GRFS, EBMT risk score &gt; 2 (<jats:italic>p<\/jats:italic> &lt; 0.001), being male (<jats:italic>p<\/jats:italic> = 0.028), and hematologic malignancy (<jats:italic>p<\/jats:italic> = 0.010) were significant for poor outcome. The events between 1\u2010year GRFS and 2\u2010year GRFS predominantly increased in relapsed patients. With prognostic factors of GRFS, we could evaluate the probability of real recovery following HSCT without ongoing morbidity.<\/jats:p>","DOI":"10.1155\/2016\/5143071","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T23:44:03Z","timestamp":1459381443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prognostic Factors on the Graft\u2010versus\u2010Host Disease\u2010Free and Relapse\u2010Free Survival after Adult Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.1155","volume":"2016","author":[{"given":"Yao-Chung","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Hsuan","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nai-Wen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Hung","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyh-Pyng","family":"Gau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Jen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-Tsai","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzeon-Jye","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hwai","family":"Tzeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Hwang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12497"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.10.026"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-332007"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1947"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3750"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.06.009"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.40.2362"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-012-1541-z"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13357"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2015.01.002"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(14)70017-8"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu364"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.110"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6205"},{"key":"e_1_2_8_15_2","unstructured":"Bolanos-MeadeJ. 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