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The mice were pretreated for 7 days with DAL followed by a single injection of DXR (10\u2009mg\/kg) via the tail vein. Renal function was analyzed 5 weeks after DXR treatment. DXR caused nephrotoxicity. The symptoms of nephrotic syndrome were greatly improved after DAL treatment. The indices of renal fibrosis, the phosphorylation of Smad3, and the expression of alpha-smooth muscle actin (<jats:italic>\u03b1<\/jats:italic>-SMA), fibronectin, collagen III (Col III), E-cadherin, TGF-<jats:italic>\u03b2<\/jats:italic>, and Smad7 in response to DXR were all similarly modified by DAL. The present findings suggest that DAL improved the markers for kidney damage investigated in this model of DXR-induced experimental nephrotoxicity.<\/jats:p>","DOI":"10.1155\/2016\/5147571","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T21:36:41Z","timestamp":1482529001000},"page":"1-10","source":"Crossref","is-referenced-by-count":10,"title":["Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-<i>\u03b2<\/i>Signal Pathway"],"prefix":"10.1155","volume":"2016","author":[{"given":"Xianguo","family":"Ren","sequence":"first","affiliation":[{"name":"National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"},{"name":"Department of Pediatrics, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 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