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However, the details of the effect\u2019s mechanism remain unknown. The aim of this study is to investigate whether adipose tissue\u2010derived stem cells (ADSCs) can ameliorate cavernous nerve injury\u2010induced erectile dysfunction (CNIED) rats and to determine its mechanism. Twenty\u2010eight days after intracavernous injection of 5\u2010ethynyl\u20102\u2010deoxyuridine\u2010 (EdU\u2010) labeled ADSCs, the erectile function of all the rats was evaluated by intracavernosal pressure (ICP). The ADSCs steadily secreted detectable pigment epithelium\u2010derived factor (PEDF) <jats:italic>in vitro<\/jats:italic>. The expression of PEDF increased in the penis of the bilateral cavernous nerve injury (BCNI) group for 14 days and then gradually decreased. On day 28 after the intracavernous injection, the ADSCs group exhibited a significantly increased ICP compared with the phosphate buffered saline\u2010 (PBS\u2010) treated group. 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