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Data on copper chelation are, however, sparse. The effect of the clinically used copper chelator D\u2010penicillamine in the catecholamine model of acute myocardial injury was tested in cardiomyoblast cell line H9c2 and in Wistar Han rats. D\u2010Penicillamine had a protective effect against catecholamine\u2010induced injury both<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>. It protected H9c2 cells against the catecholamine\u2010induced viability loss in a dose\u2010dependent manner. In animals, both intravenous D\u2010penicillamine doses of 11 (low) and 44\u2009mg\/kg (high) decreased the mortality caused by s.c. isoprenaline (100\u2009mg\/kg) from 36% to 14% and 22%, respectively. However, whereas the low D\u2010penicillamine dose decreased the release of cardiac troponin T (specific marker of myocardial injury), the high dose resulted in an increase. Interestingly, the high dose led to a marked elevation in plasma vitamin C. This might be related to potentiation of oxidative stress, as suggested by additional<jats:italic>in vitro<\/jats:italic>experiments with D\u2010penicillamine (iron reduction and the Fenton reaction). In conclusion, D\u2010penicillamine has protective potential against catecholamine\u2010induced cardiotoxicity; however the optimal dose selection seems to be crucial for further application.<\/jats:p>","DOI":"10.1155\/2016\/5213532","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T21:00:51Z","timestamp":1450126851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Protective Effects of D\u2010Penicillamine on Catecholamine\u2010Induced Myocardial Injury"],"prefix":"10.1155","volume":"2016","author":[{"given":"Michal","family":"\u0158\u00edha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavl\u00edna","family":"Ha\u0161kov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Filipsk\u00fd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate\u0159ina","family":"V\u00e1\u0148ov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslava","family":"V\u00e1vrov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Hole\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Homola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libor","family":"V\u00edtek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladim\u00edr","family":"Palicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"\u0160im\u016fnek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u0159emysl","family":"Mlad\u011bnka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,14]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-012-0226-3"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.02.032"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1015923202082"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.3.1102"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx800331j"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1139\/y2012-009"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi028"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1987.253.6.H1372"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.05.003"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2014.901510"},{"key":"e_1_2_9_11_2","first-page":"420","article-title":"The time course of serum copper concentrations of patients with myocardial infarctions .1","volume":"1","author":"Vallee B. 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