{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:38:33Z","timestamp":1765827513914,"version":"3.37.3"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Urology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Indigo carmine (also known as<jats:italic>5,5<\/jats:italic>\u2032-<jats:italic>indigodisulfonic acid sodium salt<\/jats:italic>or<jats:italic>indigotine<\/jats:italic>) is a blue dye that is administered intravenously to examine the urinary tract and usually is biologically safe and inert. Indigo carmine rarely may cause adverse reactions. We treated a 66-year-old man who had general anesthesia and radical retropubic prostatectomy for prostate cancer. He had a previous history of allergy to bee sting with nausea, vomiting, and dizziness. Within 1 minute after injection of indigo carmine for evaluation of the ureters, the patient developed hypotension to 40 mmHg, severe hypoxia (the value of SpO2 (peripheral capillary oxygen saturation) was 75% on 40% inspired oxygen concentration), poor air movement and bilateral diffuse wheezing on auscultation, and marked subcutaneous erythema at the upper extremities. After treatment with 100% oxygen, epinephrine (total, 1.5\u2009mg), hydrocortisone (100\u2009mg), diphenhydramine (50\u2009mg), albuterol nebulizer (0.083%), and continuous infusion of epinephrine (0.15\u2009<jats:italic>\u03bc<\/jats:italic>g\/kg\/min), the vital signs became stable, and he recovered completely. In summary, indigo carmine rarely may cause life-threatening anaphylactic or anaphylactoid reaction that may necessitate rapid treatment to stabilize cardiovascular, hemodynamic, and pulmonary function.<\/jats:p>","DOI":"10.1155\/2016\/5237387","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T17:02:43Z","timestamp":1471366963000},"page":"1-3","source":"Crossref","is-referenced-by-count":1,"title":["Severe Hypotension, Hypoxia, and Subcutaneous Erythema Induced by Indigo Carmine Administration during Open Prostatectomy"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2665-5964","authenticated-orcid":true,"given":"Koichiro","family":"Nandate","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Harborview Medical Center, University of Washington, 325 Ninth Avenue, P.O. Box 359724, Seattle, WA 98104-2499, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan B.","family":"Voelzke","sequence":"additional","affiliation":[{"name":"Department of Urology, Harborview Medical Center, University of Washington, 325 Ninth Avenue, P.O. Box 359868, Seattle, WA 98104-2499, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.3.6.570"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(77)90192-3"},{"issue":"1","key":"3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0022-5347(17)58715-7","volume":"116","year":"1976","journal-title":"Journal of Urology"},{"issue":"10","key":"4","first-page":"1049","volume":"66","year":"1987","journal-title":"Anesthesia & Analgesia"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199308000-00024"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(94)80149-5"},{"volume":"56, article 508","journal-title":"Urology","year":"2000","key":"7"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e318211496c"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(93)90041-5"}],"container-title":["Case Reports in Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criu\/2016\/5237387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criu\/2016\/5237387.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criu\/2016\/5237387.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T12:27:28Z","timestamp":1568291248000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criu\/2016\/5237387\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":9,"alternative-id":["5237387","5237387"],"URL":"https:\/\/doi.org\/10.1155\/2016\/5237387","relation":{},"ISSN":["2090-696X","2090-6978"],"issn-type":[{"type":"print","value":"2090-696X"},{"type":"electronic","value":"2090-6978"}],"subject":[],"published":{"date-parts":[[2016]]}}}