{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:05:51Z","timestamp":1768550751760,"version":"3.49.0"},"reference-count":35,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004813","name":"Helmholtz Centre for Environmental Research","doi-asserted-by":"crossref","award":["SAB 713-257022"],"award-info":[{"award-number":["SAB 713-257022"]}],"id":[{"id":"10.13039\/501100004813","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Leipzig Research Center for Civilization Diseases","award":["SAB 713-257022"],"award-info":[{"award-number":["SAB 713-257022"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["SAB 713-257022"],"award-info":[{"award-number":["SAB 713-257022"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["SAB 713-257022"],"award-info":[{"award-number":["SAB 713-257022"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Environmental and Public Health"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Enhanced eosinophil\/basophil (Eo\/B) progenitor cell levels are known to be associated with allergic inflammation and atopy risk. The aim of the present study was to investigate the influence of different indoor exposures on the recruitment and differentiation of Eo\/B progenitors in mother-child pairs.<jats:italic>Methods<\/jats:italic>. In 68 mother-child pairs of the LINA study peripheral blood mononuclear cells were used to assess Eo\/B colony forming units (CFUs). Information about disease outcomes and indoor exposures was obtained from questionnaires. Indoor concentrations of volatile organic compounds (VOCs) were measured by passive sampling.<jats:italic>Results<\/jats:italic>. Infant\u2019s Eo\/B CFUs were positively associated with exposure to tobacco smoke, disinfectants, or VOCs. In contrast, for maternal Eo\/B CFUs, only a few associations were seen. Higher numbers of infant Eo\/B CFUs were observed in children with wheezing symptoms within the second year of life.<jats:italic>Conclusions<\/jats:italic>. We demonstrate that infant\u2019s hematopoietic cells seem to respond with more sensitivity to environmental exposure compared to maternal cells. At least in infants, an activation of these hematopoietic cells by environmental exposure could contribute to an enhanced risk for the development of respiratory outcomes.<\/jats:p>","DOI":"10.1155\/2016\/5293932","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T21:01:29Z","timestamp":1464296489000},"page":"1-10","source":"Crossref","is-referenced-by-count":8,"title":["The LINA Study: Higher Sensitivity of Infant Compared to Maternal Eosinophil\/Basophil Progenitors to Indoor Chemical Exposures"],"prefix":"10.1155","volume":"2016","author":[{"given":"Friederike","family":"H\u00f6rnig","sequence":"first","affiliation":[{"name":"Helmholtz Centre for Environmental Research (UFZ), Leipzig, Department of Environmental Immunology, Permoserstra\u00dfe 15, 04318 Leipzig, Germany"},{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Philipp-Rosenthal-Stra\u00dfe 27, 04103 Leipzig, 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