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Maraviroc has been shown to have potent anti-inflammatory effects. The aim of this study was to investigate whether PPAR<jats:italic>\u03b3<\/jats:italic>plays an important role in maraviroc-mediated lung protection following trauma-hemorrhage.<jats:italic>Methods.<\/jats:italic>Male Sprague-Dawley rats underwent trauma-hemorrhage (mean blood pressure maintained at approximately 35\u201340\u2009mmHg for 90 minutes), followed by fluid resuscitation. During resuscitation, a single dose of maraviroc (3\u2009mg\/kg, intravenously) with and without a PPAR<jats:italic>\u03b3<\/jats:italic>inhibitor GW9662 (1\u2009mg\/kg, intravenously), GW9662, or vehicle was administered. Lung water content, tissue histology, and other various parameters were measured (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">8<\/mml:mn><\/mml:math>rats\/group) 24 hours after resuscitation. One-way ANOVA and Tukey\u2019s testing were used for statistical analysis.<jats:italic>Results.<\/jats:italic>Trauma-hemorrhage significantly increased lung water content, myeloperoxidase activity, intercellular adhesion molecule-1, interleukin-6, and interleukin-1<jats:italic>\u03b2<\/jats:italic>levels. These parameters significantly improved in the maraviroc-treated rats subjected to trauma-hemorrhage. Maraviroc treatment also decreased lung tissue damage as compared to the vehicle-treated trauma-hemorrhaged rats. Coadministration of GW9662 with maraviroc abolished the maraviroc-induced beneficial effects on these parameters and lung injury.<jats:italic>Conclusion.<\/jats:italic>These results suggest that PPAR<jats:italic>\u03b3<\/jats:italic>might play a key role in maraviroc-mediated lung protection following trauma-hemorrhage.<\/jats:p>","DOI":"10.1155\/2016\/5302069","type":"journal-article","created":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T21:03:35Z","timestamp":1469999015000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Maraviroc-Mediated Lung Protection following Trauma-Hemorrhagic Shock"],"prefix":"10.1155","volume":"2016","author":[{"given":"Fu-Chao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 33302, 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