{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:28:20Z","timestamp":1770704900722,"version":"3.49.0"},"reference-count":84,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institutional Development Awards (IDeA)","award":["P20GM103408"],"award-info":[{"award-number":["P20GM103408"]}]},{"name":"Institutional Development Awards (IDeA)","award":["P20GM109095"],"award-info":[{"award-number":["P20GM109095"]}]},{"name":"Institutional Development Awards (IDeA)","award":["0619793"],"award-info":[{"award-number":["0619793"]}]},{"name":"Institutional Development Awards (IDeA)","award":["0923535"],"award-info":[{"award-number":["0923535"]}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103408"],"award-info":[{"award-number":["P20GM103408"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM109095"],"award-info":[{"award-number":["P20GM109095"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["0619793"],"award-info":[{"award-number":["0619793"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["0923535"],"award-info":[{"award-number":["0923535"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM103408"],"award-info":[{"award-number":["P20GM103408"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM109095"],"award-info":[{"award-number":["P20GM109095"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["0619793"],"award-info":[{"award-number":["0619793"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["0923535"],"award-info":[{"award-number":["0923535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM103408"],"award-info":[{"award-number":["P20GM103408"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM109095"],"award-info":[{"award-number":["P20GM109095"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["0619793"],"award-info":[{"award-number":["0619793"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["0923535"],"award-info":[{"award-number":["0923535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biomolecular Research Center at Boise State University","award":["P20GM103408"],"award-info":[{"award-number":["P20GM103408"]}]},{"name":"Biomolecular Research Center at Boise State University","award":["P20GM109095"],"award-info":[{"award-number":["P20GM109095"]}]},{"name":"Biomolecular Research Center at Boise State University","award":["0619793"],"award-info":[{"award-number":["0619793"]}]},{"name":"Biomolecular Research Center at Boise State University","award":["0923535"],"award-info":[{"award-number":["0923535"]}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["P20GM103408"],"award-info":[{"award-number":["P20GM103408"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["P20GM109095"],"award-info":[{"award-number":["P20GM109095"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["0619793"],"award-info":[{"award-number":["0619793"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["0923535"],"award-info":[{"award-number":["0923535"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["P20GM103408"],"award-info":[{"award-number":["P20GM103408"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["P20GM109095"],"award-info":[{"award-number":["P20GM109095"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["0619793"],"award-info":[{"award-number":["0619793"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["0923535"],"award-info":[{"award-number":["0923535"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000937","name":"MJ Murdock Charitable Trust","doi-asserted-by":"crossref","award":["P20GM103408"],"award-info":[{"award-number":["P20GM103408"]}],"id":[{"id":"10.13039\/100000937","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000937","name":"MJ Murdock Charitable Trust","doi-asserted-by":"crossref","award":["P20GM109095"],"award-info":[{"award-number":["P20GM109095"]}],"id":[{"id":"10.13039\/100000937","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000937","name":"MJ Murdock Charitable Trust","doi-asserted-by":"crossref","award":["0619793"],"award-info":[{"award-number":["0619793"]}],"id":[{"id":"10.13039\/100000937","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000937","name":"MJ Murdock Charitable Trust","doi-asserted-by":"crossref","award":["0923535"],"award-info":[{"award-number":["0923535"]}],"id":[{"id":"10.13039\/100000937","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013375","name":"Idaho State Board of Education","doi-asserted-by":"crossref","award":["P20GM103408"],"award-info":[{"award-number":["P20GM103408"]}],"id":[{"id":"10.13039\/100013375","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013375","name":"Idaho State Board of Education","doi-asserted-by":"crossref","award":["P20GM109095"],"award-info":[{"award-number":["P20GM109095"]}],"id":[{"id":"10.13039\/100013375","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013375","name":"Idaho State Board of Education","doi-asserted-by":"crossref","award":["0619793"],"award-info":[{"award-number":["0619793"]}],"id":[{"id":"10.13039\/100013375","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013375","name":"Idaho State Board of Education","doi-asserted-by":"crossref","award":["0923535"],"award-info":[{"award-number":["0923535"]}],"id":[{"id":"10.13039\/100013375","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>The aryl hydrocarbon receptor (AhR) is a soluble, ligand-activated transcription factor that mediates the toxicity of 2,3,7,8-tetrachlorodibenzo-<jats:italic>p<\/jats:italic>-dioxin (TCDD). Increasing evidence implicates the AhR in regulating extracellular matrix (ECM) homeostasis. We recently reported that TCDD increased necroinflammation and myofibroblast activation during liver injury elicited by carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>). However, TCDD did not increase collagen deposition or exacerbate fibrosis in CCl<jats:sub>4<\/jats:sub>-treated mice, which raises the possibility that TCDD may enhance ECM turnover. The goal of this study was to determine how TCDD impacts ECM remodeling gene expression in the liver. Male C57BL\/6 mice were treated for 8 weeks with 0.5\u2009mL\/kg CCl<jats:sub>4<\/jats:sub>, and TCDD (20\u2009<jats:italic>\u03bc<\/jats:italic>g\/kg) was administered during the last two weeks. Results indicate that TCDD increased mRNA levels of procollagen types I, III, IV, and VI and the collagen processing molecules HSP47 and lysyl oxidase. TCDD also increased gelatinase activity and mRNA levels of matrix metalloproteinase- (MMP-) 3, MMP-8, MMP-9, and MMP-13. Furthermore, TCDD modulated expression of genes in the plasminogen activator\/plasmin system, which regulates MMP activation, and it also increased TIMP1 gene expression. These findings support the notion that AhR activation by TCDD dysregulates ECM remodeling gene expression and may facilitate ECM metabolism despite increased liver injury.<\/jats:p>","DOI":"10.1155\/2016\/5309328","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T21:08:28Z","timestamp":1473368908000},"page":"1-14","source":"Crossref","is-referenced-by-count":12,"title":["Aryl Hydrocarbon Receptor Activation by TCDD Modulates Expression of Extracellular Matrix Remodeling Genes during Experimental Liver Fibrosis"],"prefix":"10.1155","volume":"2016","author":[{"given":"Cheri L.","family":"Lamb","sequence":"first","affiliation":[{"name":"Biomolecular Sciences Ph.D. Program, Boise State University, Boise, ID 83725, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovan N.","family":"Cholico","sequence":"additional","affiliation":[{"name":"Biomolecular Sciences Ph.D. Program, Boise State University, Boise, ID 83725, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Boise State University, Boise, ID 83725, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Fewkes","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Boise State University, Boise, ID 83725, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia Thom","family":"Oxford","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Boise State University, Boise, ID 83725, USA"},{"name":"Biomolecular Research Center, Boise State University, Boise, ID 83725, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor J.","family":"Lujan","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Biomedical Engineering, Boise State University, Boise, ID 83725, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica E.","family":"Morrill","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Biomedical Engineering, Boise State University, Boise, ID 83725, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8872-0579","authenticated-orcid":true,"given":"Kristen A.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Biomolecular Sciences Ph.D. Program, Boise State University, Boise, ID 83725, USA"},{"name":"Department of Biological Sciences, Boise State University, Boise, ID 83725, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v18.i3.20"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.35.040195.001515"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.40.1.519"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.0210"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1039\/c4tx00236a"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.10.028"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.03.046"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00447.2014"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1530\/joe-10-0377"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj118"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm272"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.07.010"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-002-0338-6"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kft236"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.11.043"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402168200"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2005.05.001"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl119"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2247"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.01.004"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2007"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1998.8547"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3823"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.023820"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208072109"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.136.3.729"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.50.31767"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20776"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-268425"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0581"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.12.002"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.8.5288"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119964109"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-016-0776-3"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201100335"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/bf01002772"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.2009.954354"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110405"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01731"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1007\/bf01002772"},{"issue":"2","key":"44","first-page":"97","volume":"22","year":"2005","journal-title":"Journal of Morphological Science"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2009.09.015"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.11.002"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.075952"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-002-0354-6"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.203786"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1172\/jci200522675"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(99)80007-5"},{"issue":"1","key":"52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1755-1536-5-1","volume":"5","year":"2012","journal-title":"Fibrogenesis & Tissue Repair"},{"issue":"4","key":"53","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0016-5085(79)80170-5","volume":"76","year":"1979","journal-title":"Gastroenterology"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfi301"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2008.07.008"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1042\/bj2440075"},{"issue":"2, article 9","key":"57","volume":"1","year":"2014","journal-title":"Austin Biomarkers & Diagnosis"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2016.02.001"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504757102"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.047274"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1126\/science.7732381"},{"issue":"2","key":"62","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1124\/mol.54.2.313","volume":"54","year":"1998","journal-title":"Molecular Pharmacology"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1002\/path.4433"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m114.592139"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.12.001"},{"issue":"8","key":"66","first-page":"967","volume":"78","year":"1998","journal-title":"Laboratory Investigation"},{"issue":"3","key":"67","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00441-003-0699-z","volume":"311","year":"2003","journal-title":"Cell and Tissue Research"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1369\/0022155412438104"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.09.002"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.00323-07"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10413"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1515\/bc.2006.144"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m402168200"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1385\/CT:4:4:363"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.01.113"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300432"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.03.005"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3701-1-14"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00063"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.51.569"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.12.004"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/69.2.409"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1995.1124"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2789"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-4652(199910)181:1<96::aid-jcp10>3.0.co;2-i"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2012.04.008"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/5309328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/5309328.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/5309328.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T21:34:15Z","timestamp":1601069655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2016\/5309328\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":84,"alternative-id":["5309328","5309328"],"URL":"https:\/\/doi.org\/10.1155\/2016\/5309328","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}