{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:11:24Z","timestamp":1791357084626,"version":"4.3.1"},"reference-count":68,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009347","name":"Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz","doi-asserted-by":"publisher","award":["NC093370.2"],"award-info":[{"award-number":["NC093370.2"]}],"id":[{"id":"10.13039\/501100009347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Journal"],"published-print":{"date-parts":[[2016,6,28]]},"abstract":"<jats:p>In a previous study, we found that chronic mild stress (CMS) paradigm did not induce anhedonia in young-adult male rats but it reduced their body weight gain. These contrasting results encouraged us to explore other indicators of animal\u2019s vulnerability to stress such as anxious-like behaviors, since stress is an etiologic factor also for anxiety. Thus, in this study, we evaluated the vulnerability of these animals to CMS using behavioral tests of depression or anxiety and measuring serum corticosterone. Male Wistar rats were exposed to four weeks of CMS; the animals\u2019 body weight and sucrose preference (indicator of anhedonia) were assessed after three weeks, and, after the fourth week, some animals were evaluated in a behavioral battery (elevated plus maze, defensive burying behavior, and forced swimming tests); meanwhile, others were used to measure serum corticosterone. We found that CMS (1) did not affect sucrose preference, immobility behavior in the forced swimming test, or serum corticosterone; (2) decreased body weight gain; and (3) increased the rat\u2019s entries into closed arms of the plus maze and the cumulative burying behavior. These data indicate that young male rats\u2019 vulnerability to CMS is reflected as poor body weight gain and anxious-like instead of depressive-like behaviors.<\/jats:p>","DOI":"10.1155\/2016\/5317242","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T13:24:04Z","timestamp":1467206644000},"page":"1-12","source":"Crossref","is-referenced-by-count":21,"title":["Young-Adult Male Rats\u2019 Vulnerability to Chronic Mild Stress Is Reflected by Anxious-Like instead of Depressive-Like Behaviors"],"prefix":"10.1155","volume":"2016","author":[{"given":"Herrera-P\u00e9rez","family":"Jos\u00e9 Jaime","sequence":"first","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda Conductual, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Calzada M\u00e9xico-Xochimilco 101, Colonia San Lorenzo Huipulco, Delegaci\u00f3n Tlalpan, 14370 Ciudad de M\u00e9xico, DF, 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