{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:08:14Z","timestamp":1790687294595,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["EY03040"],"award-info":[{"award-number":["EY03040"]}]},{"name":"NIH","award":["EEC 0310723 (BMES-ERC)"],"award-info":[{"award-number":["EEC 0310723 (BMES-ERC)"]}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["EY03040"],"award-info":[{"award-number":["EY03040"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["EEC 0310723 (BMES-ERC)"],"award-info":[{"award-number":["EEC 0310723 (BMES-ERC)"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Purpose.<\/jats:italic>To study the safety of intravitreal injections of poly-N-isopropylacrylamide (pNIPAM) tissue adhesive in rabbit eyes.<jats:italic>Methods.<\/jats:italic>Twelve study rabbits received an intravitreal injection of 0.1\u2009mL 50% pNIPAM in the right eye. Follow-up examinations included color fundus photography, fundus fluorescein angiography (FA), optical coherence tomography (OCT), and electroretinography (ERG). Subsequent to the last follow-up assessment, the rabbits were sacrificed and histopathological study on the scleral incision sites was performed.<jats:italic>Results.<\/jats:italic>All study animals developed mild to moderate levels of inflammatory reaction in the conjunctiva, anterior chamber, and the anterior vitreous during the first month of follow-up. After this period, the level of the inflammatory reaction progressively decreased and completely disappeared after the third month of follow-up. The lens and cornea remained clear during the entire follow-up period. OCT and FA did not show areas of retinal damage or neovascularization. Histological and ERG studies of eyes injected with pNIPAM demonstrated absence of retinal toxicity.<jats:italic>Conclusion.<\/jats:italic>Intravitreal injections of pNIPAM were nontoxic in this animal study, and pNIPAM may be safe to be used as a bioadhesive in certain retinal diseases.<\/jats:p>","DOI":"10.1155\/2016\/5356371","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T21:00:43Z","timestamp":1478034043000},"page":"1-6","source":"Crossref","is-referenced-by-count":54,"title":["Ocular Biocompatibility of Poly-N-Isopropylacrylamide (pNIPAM)"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-909X","authenticated-orcid":true,"given":"Luiz H.","family":"Lima","sequence":"first","affiliation":[{"name":"Doheny Eye Institute, University of California, Los Angeles (UCLA), Los Angeles, CA, USA"},{"name":"Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Morales","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, University of California, Los Angeles (UCLA), Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Cabral","sequence":"additional","affiliation":[{"name":"Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil"},{"name":"Federal University of Esp\u00edrito Santo (UFES), Vit\u00f3ria, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(98)80343-X"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(82)34649-7"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(83)34508-5"},{"issue":"7","key":"4","first-page":"446","volume":"25","year":"1994","journal-title":"Ophthalmic Surgery"},{"issue":"2","key":"5","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3928\/1542-8877-19970201-07","volume":"28","year":"1997","journal-title":"Ophthalmic Surgery and Lasers"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70695-6"},{"issue":"6","key":"7","first-page":"367","volume":"5","year":"1996","journal-title":"Journal of Glaucoma"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/s0886-3350(98)80055-2"},{"issue":"4","key":"9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3928\/1542-8877-19960401-05","volume":"27","year":"1996","journal-title":"Ophthalmic Surgery and Lasers"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/s0886-3350(13)80141-1"},{"issue":"11","key":"11","first-page":"324","volume":"18","year":"1986","journal-title":"Annals of Ophthalmology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.75.5.309"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070010591036"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00930314"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)75574-6"},{"key":"16","first-page":"353","volume-title":"Synthetic retinal glue","volume":"3","year":"1989"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1080\/10601326808051910"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-3659(01)00319-4"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(02)00041-8"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820290705"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-3659(99)00029-2"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(95)93257-E"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1021\/bm0343601"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/s0142-9612(01)00127-2"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00035-8"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1163\/156856296X00138"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200402000-00011"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/2\/1\/009"},{"issue":"2","key":"29","first-page":"159","volume":"70","year":"2004","journal-title":"Journal of Biomedical Materials Research Part A"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/s0001-8686(99)00023-8"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(86)90145-5"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(86)90398-3"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(87)90003-1"},{"issue":"3","key":"34","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3928\/1542-8877-19980301-10","volume":"29","year":"1998","journal-title":"Ophthalmic Surgery and Lasers"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(98)00312-5"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/s0042-6989(99)00052-8"},{"issue":"9","key":"37","first-page":"2073","volume":"40","year":"1999","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"38","first-page":"47","volume":"112","year":"1996","journal-title":"IEEE Spectrum"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-4636(19980615)40:4<631::aid-jbm15>3.0.co;2-i"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1159\/000076649"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2016\/5356371.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2016\/5356371.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2016\/5356371.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T23:33:16Z","timestamp":1657582396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2016\/5356371\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":40,"alternative-id":["5356371","5356371"],"URL":"https:\/\/doi.org\/10.1155\/2016\/5356371","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}