{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:44:15Z","timestamp":1740170655245,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of National Defense in Warsaw","award":["328"],"award-info":[{"award-number":["328"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2016]]},"abstract":"We examined the real-world utilization and persistence of rapid acting insulin (RAI) in elderly patients with type 2 diabetes who added RAI to their drug (OAD) regimen. Insulin-na\u00efve patients aged \u226565 years, with \u22651 OAD prescription during the baseline period, who were continuously enrolled in the US Humana Medicare Advantage insurance plan for 18 months and initiated RAI were included. Among patients with \u22652 RAI prescriptions (RAIp), persistence during the 12-month follow-up was assessed. Multivariate logistic regression analyses identified factors affecting RAI use and persistence. Of 3734 patients adding RAI to their OAD regimen, 2334 (62.5%) had a RAIp during follow-up. Factors associated with RAIp included using \u22642 OADs; cognitive impairment, basal insulin use during follow-up; and higher RAI out-of-pocket costs ($<\/mml:mtext><\/mml:mrow><\/mml:math>36 to <$<\/mml:mtext><\/mml:mrow><\/mml:math>56 versus$<\/mml:mtext><\/mml:mrow><\/mml:math>0 to$<\/mml:mtext><\/mml:mrow><\/mml:math>6.30). Patients were less likely to persist with RAI when on \u22642 OADs versus \u22653 OADs and when having higher RAI out-of-pocket costs ($<\/mml:mtext><\/mml:mrow><\/mml:math>36 to <$<\/mml:mtext><\/mml:mrow><\/mml:math>56 versus$<\/mml:mtext><\/mml:mrow><\/mml:math>0 to$<\/mml:mtext><\/mml:mrow><\/mml:math>6.30) and more likely to persist when they had cognitive impairment and basal insulin use during follow-up. Real-world persistence of RAI in insulin-na\u00efve elderly patients with type 2 diabetes was very poor when RAI was added to an OAD regimen.<\/jats:p>","DOI":"10.1155\/2016\/5374931","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T21:10:45Z","timestamp":1475097045000},"page":"1-12","source":"Crossref","is-referenced-by-count":3,"title":["Rapid Acting Insulin Use and Persistence among Elderly Type 2 Diabetes Patients Adding RAI to Oral Antidiabetes Drug Regimens"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8311-1360","authenticated-orcid":true,"given":"Usha","family":"Sambamoorthi","sequence":"first","affiliation":[{"name":"School of Pharmacy, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4570-0364","authenticated-orcid":true,"given":"Arijita","family":"Deb","sequence":"additional","affiliation":[{"name":"School of Pharmacy, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Zhou","sequence":"additional","affiliation":[{"name":"Sanofi US, Inc., Bridgewater, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0236-7370","authenticated-orcid":true,"given":"Rahul","family":"Garg","sequence":"additional","affiliation":[{"name":"School of Pharmacy, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Fan","sequence":"additional","affiliation":[{"name":"Sanofi US, Inc., Bridgewater, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8575-5175","authenticated-orcid":true,"given":"Anders","family":"Boss","sequence":"additional","affiliation":[{"name":"Sanofi US, Inc., Bridgewater, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s1262-3636(07)70241-0"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2008.00846.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2441"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2337\/diaspect.27.2.87"},{"first-page":"169","volume-title":"The transition from oral agents to combination insulin\/oral therapy","year":"2008","key":"5"},{"issue":"1","key":"6","first-page":"181","volume":"27","year":"2003","journal-title":"Collegium 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