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The pathogenesis of BD is still unknown. Aberrant production of some cytokines\/chemokines plays an important role in the pathogenesis of various inflammatory diseases. Revealing a key signaling regulatory mechanism involved in proinflammatory cytokines\/chemokines production is critical for understanding of the pathogenesis of BD. The aim of this study was to determine the role of Src family kinases (SFKs) in production of some LPS-induced proinflammatory cytokines\/chemokines in peripheral blood mononuclear cells (PBMC) of active BD patients. Chemical inhibition of SFKs activity impaired LPS-induced TNF-<jats:italic>\u03b1<\/jats:italic>production in PBMC of active BD patients, suggesting that modulating SFKs activity may be a potential target for BD treatment.<\/jats:p>","DOI":"10.1155\/2016\/5414369","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T22:27:58Z","timestamp":1467325678000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-<i>\u03b1<\/i>Production in PBMC of Patients with Beh\u00e7et\u2019s Disease"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6160-5626","authenticated-orcid":true,"given":"Sevgi","family":"Irtegun","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Dicle University, 21280 Diyarbak\u0131r, 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