{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:26:55Z","timestamp":1774452415608,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>One of the regions of involvement of Beh\u00e7et\u2019s disease (BD), a systematic inflammatory vasculitis with unknown etiology, is the gastrointestinal (GI) tract. Upper GI endoscopy, colonoscopy, and capsule endoscopy are frequently used methods to diagnose the intestinal involvement of BD. The aim of this study was to investigate the role of fecal calprotectin (FC) in the evaluation of intestinal involvement in BD.<jats:italic>Material and Method<\/jats:italic>. A total of 30 patients who were diagnosed with BD and had no GI symptoms and 25 individuals in the control group were included in this study.<jats:italic>Results<\/jats:italic>. Levels of FC were statistically significantly higher in patients with BD compared to the control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). The correlation analysis performed including FC and markers of disease activity revealed a positive and statistically significant correlation between FC level and CRP and erythrocyte sedimentation rate (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>r<\/mml:mi><\/mml:mrow><\/mml:math>: 0.255,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.049<\/mml:mn><\/mml:math>, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>r<\/mml:mi><\/mml:mrow><\/mml:math>: 0.404,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>, resp.). FC levels in patients who were detected to have ulcers in the terminal ileum and colon in the colonoscopic examination were statistically significantly higher compared to the patients with BD without intestinal involvement (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. The measurement of FC levels, in patients with BD who are asymptomatic for GI involvement, may be helpful to detect the possible underlying intestinal involvement.<\/jats:p>","DOI":"10.1155\/2016\/5423043","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T17:14:41Z","timestamp":1472058881000},"page":"1-5","source":"Crossref","is-referenced-by-count":18,"title":["The Role of Fecal Calprotectin in Evaluating Intestinal Involvement of Beh\u00e7et\u2019s Disease"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5429-513X","authenticated-orcid":true,"given":"Burak","family":"\u00d6z\u015feker","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, 48000 Mu\u011fla, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, 48000 Mu\u011fla, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Havva Solak","family":"\u00d6z\u015feker","sequence":"additional","affiliation":[{"name":"Department of Pathology, Education and Research Hospital, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, 48000 Mu\u011fla, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Cumali","family":"Efe","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Batman State Hospital, 72070 Batman, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2879-7739","authenticated-orcid":true,"given":"Taylan","family":"Kav","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, School of Medicine, Hacettepe University, 06230 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Bayraktar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, School of Medicine, Hacettepe University, 06230 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199910213411707"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92643-v"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2009.24.1.52"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/bf02235590"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.188.1.8511319"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2014.984319"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i7.609"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01741.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2090-4"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1159\/000264643"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-861429"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken216"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3369"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1159\/000442935"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/mib.0000000000000736"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2147\/ceg.s51902"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2016.752"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/5423043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/5423043.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/5423043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T17:14:42Z","timestamp":1472058882000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/dm\/2016\/5423043\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":17,"alternative-id":["5423043","5423043"],"URL":"https:\/\/doi.org\/10.1155\/2016\/5423043","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}