{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:31:08Z","timestamp":1740177068147,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. There is limited data evaluating physician transfusion practices in patients with acute upper gastrointestinal bleeding (UGIB).<jats:italic>Methods<\/jats:italic>. A web-based survey was sent to 500 gastroenterologists and hepatologists across Canada. The survey included clinical vignettes where physicians were asked to choose transfusion thresholds.<jats:italic>Results<\/jats:italic>. The response rate was 41% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>N<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">203<\/mml:mn><\/mml:math>). The reported hemoglobin (Hgb) transfusion trigger differed by up to 50\u2009g\/L. Transfusions were more liberal in hemodynamically unstable patients compared to stable patients (mean Hgb of 86.7\u2009g\/L versus 71.0\u2009g\/L;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). Many clinicians (24%) reported transfusing a hemodynamically unstable patient at a Hgb threshold of 100\u2009g\/L and the majority (57%) are transfusing two units of RBCs as initial management. Patients with coronary artery disease (mean Hgb of 84.0\u2009g\/L versus 71.0\u2009g\/L;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>) or cirrhosis (mean Hgb of 74.4\u2009g\/L versus 71.0\u2009g\/L;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>) were transfused more liberally than healthy patients. Fewer than 15% would prescribe iron to patients with UGIB who are anemic upon discharge.<jats:italic>Conclusions<\/jats:italic>. The transfusion practices of gastroenterologists in the management of UGIB vary widely and more high-quality evidence is needed to help assess the efficacy and safety of selected transfusion thresholds in varying patients presenting with UGIB.<\/jats:p>","DOI":"10.1155\/2016\/5610838","type":"journal-article","created":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T17:31:21Z","timestamp":1467135081000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Red Blood Cell Transfusions and Iron Therapy for Patients Presenting with Acute Upper Gastrointestinal Bleeding: A Survey of Canadian Gastroenterologists and Hepatologists"],"prefix":"10.1155","volume":"2016","author":[{"given":"Kyle J.","family":"Fortinsky","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-613X","authenticated-orcid":true,"given":"Myriam","family":"Martel","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics and Occupational Health, McGill University Health Center, McGill University, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshan","family":"Razik","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Spiegle","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zane R.","family":"Gallinger","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir C.","family":"Grover","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Pavenski","sequence":"additional","affiliation":[{"name":"Division of Hematology and Transfusion Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam V.","family":"Weizman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukasz","family":"Kwapisz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Western University, London, ON, 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