{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:36:49Z","timestamp":1793968609739,"version":"4.8.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"vor","delay-in-days":291,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Chlorpromazine and trimethoprim\u2010sulfamethoxazole (TMP\/SMX) are two commonly prescribed medications by physicians. Either of those medications could cause fatal drug\u2010induced agranulocytosis, with an unclear underlying mechanism. The likelihood of simultaneous prescription of both medications is high and could hypothetically result in severe agranulocytosis that is resistant to treatment.\n                    <jats:italic>Case Presentation<\/jats:italic>\n                    . We are presenting a case of a patient with psychosis on chlorpromazine who was prescribed TMP\/SMX for a urinary tract infection. Consequently, the patient developed severe agranulocytosis and septicemia. Patient was managed by granulocyte colony\u2010stimulating factor; however, the time to neutrophil recovery was delayed when compared to the average reported time published by previous studies.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Simultaneous use of chlorpromazine and TMP\/SMX is a possible toxic combination that could induce severe agranulocytosis. Further reports are needed to confirm this observation.\n                  <\/jats:p>","DOI":"10.1155\/2016\/5653497","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T17:19:12Z","timestamp":1476811152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Severe Agranulocytosis following Simultaneous Administration of Chlorpromazine and Trimethoprim\u2010Sulfamethoxazole in a Patient with Sepsis: A Possible Toxic Combination"],"prefix":"10.1155","volume":"2016","author":[{"given":"Anil","family":"Jha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Ghoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5203-7804","authenticated-orcid":false,"given":"Nicholas","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,18]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-3-15"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2008.04.003"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm195610252551703"},{"key":"e_1_2_8_4_2","first-page":"341","article-title":"Agranulocytosis in the course of phenothiazine therapy: case reports","volume":"46","author":"Yassa R.","year":"1985","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hup.917"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.16.1975"},{"key":"e_1_2_8_7_2","unstructured":"Medicina Cl\u00ednica 1988 90 Cotrimoxazole-induced agranulocytosis"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2015.985649"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08104.x"},{"key":"e_1_2_8_10_2","first-page":"784","article-title":"Agranulocytosis and chlorpromazine","volume":"39","author":"Marcus J.","year":"1978","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)90565-9"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4883.358-c"},{"key":"e_1_2_8_13_2","first-page":"1424","article-title":"Agranulocytosis due to chlorpromazine","volume":"53","author":"Rosenthal M.","year":"1957","journal-title":"The Ohio State Medical Journal"},{"key":"e_1_2_8_14_2","first-page":"355","article-title":"Agranulocytosis; report of case following use of chlorpromazine","volume":"58","author":"Zelman S.","year":"1957","journal-title":"The Journal of the Kansas Medical Society"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1990.tb00245.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1969.03160100052013"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.4.402"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.16.1975"},{"key":"e_1_2_8_19_2","first-page":"255","article-title":"Treatment of drug-induced agranulocytosis with colony stimulating factors (G-CSF or GM-CSF)","volume":"44","author":"G\u00f3ra-Tybor J.","year":"1996","journal-title":"Archivum Immunologiae et Therapiae Experimentalis"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-9-200705010-00009"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/5653497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/2016\/5653497","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/5653497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:42:12Z","timestamp":1788266532000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/5653497"}},"subtitle":[],"editor":[{"given":"Thomas R.","family":"Chauncey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/5653497"],"URL":"https:\/\/doi.org\/10.1155\/2016\/5653497","archive":["Portico"],"relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2016-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5653497"}}