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The aim of our study was to determinate the association between CD36 and LOX-1 in presence of age and abdominal obesity.<jats:italic>Methods<\/jats:italic>. This is a cross-sectional study that included 151 healthy individuals, clinically and anthropometrically classified into two groups by age (&lt;30 and \u226530 years old) and abdominal obesity (according to World Health Organization guidelines). We excluded individuals with any chronic and metabolic illness, use of medication, or smoking. Fasting blood samples were taken to perform determination of CD36 mRNA expression by real-time PCR, lipid profile and metabolic and low grade inflammation markers by routine methods, and soluble scavenger receptors (CD36 and LOX-1) by ELISA.<jats:italic>Results<\/jats:italic>. Individuals \u226530 years old with abdominal obesity presented high atherogenic index, lower soluble scavenger receptor levels, and subexpression of<jats:italic>CD36<\/jats:italic>mRNA (54% less). On the other hand, individuals &lt;30 years old with abdominal adiposity presented higher levels in the same parameters, except LOX-1 soluble levels.<jats:italic>Conclusion<\/jats:italic>. In this study, individuals over 30 years of age presented low soluble scavenger receptors levels pattern and<jats:italic>CD36<\/jats:italic>gene subexpression, which suggest the chronic metabolic dysregulation in abdominal obesity.<\/jats:p>","DOI":"10.1155\/2016\/5678946","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T21:00:50Z","timestamp":1469480450000},"page":"1-10","source":"Crossref","is-referenced-by-count":3,"title":["Low CD36 and LOX-1 Levels and<i>CD36<\/i>Gene Subexpression Are Associated with Metabolic Dysregulation in Older Individuals with Abdominal Obesity"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4882-946X","authenticated-orcid":true,"given":"Perla-Monserrat","family":"Madrigal-Ru\u00edz","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"},{"name":"Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"},{"name":"UDG-CA-701, Grupo de Investigaci\u00f3n Inmunometabolismo en Enfermedades Emergentes (GIIEE), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5531-5403","authenticated-orcid":true,"given":"Rosa-Elena","family":"Navarro-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"},{"name":"Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"},{"name":"UDG-CA-701, Grupo de Investigaci\u00f3n Inmunometabolismo en Enfermedades Emergentes (GIIEE), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3895-5123","authenticated-orcid":true,"given":"Sandra-Luz","family":"Ru\u00edz-Quezada","sequence":"additional","affiliation":[{"name":"UDG-CA-701, Grupo de Investigaci\u00f3n Inmunometabolismo en Enfermedades Emergentes (GIIEE), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"},{"name":"Departamento de Farmacobiolog\u00eda, Centro Universitario de Ciencias Exactas e Ingenier\u00edas, Universidad de Guadalajara, Boulevard Marcelino Garc\u00eda Barrag\u00e1n No. 1421, 44430 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-1482","authenticated-orcid":true,"given":"Fernanda-Isadora","family":"Corona-Meraz","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"},{"name":"UDG-CA-701, Grupo de Investigaci\u00f3n Inmunometabolismo en Enfermedades Emergentes (GIIEE), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3823-4676","authenticated-orcid":true,"given":"M\u00f3nica","family":"V\u00e1zquez-Del Mercado","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"},{"name":"Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"},{"name":"Servicio de Reumatolog\u00eda, Divisi\u00f3n de Medicina Interna, Hospital Civil \u201cDr. Juan I. 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