{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:49:53Z","timestamp":1787932193483,"version":"build-2784847793"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["2014-1-233760"],"award-info":[{"award-number":["2014-1-233760"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>The aim of the study was to characterize the presence of diverse CD4 and CD8 T cell subsets and regulatory cells in peripheral blood and lower oesophageal sphincter (LES) from a young patient with BE\/achalasia without treatment versus achalasia group. In order to characterize the circulating cells in this patient, a cytometric analysis was performed. LES tissue was evaluated by double-immunostaining procedure. Five healthy blood donors, 5 type achalasia patients, and 5 oesophagus tissue samples (gastrooesophageal junction) from transplant donors were included as control groups. A conspicuous systemic inflammation was determined in BE\/achalasia patient and achalasia versus healthy volunteer group. Nonetheless, a predominance of Th22, Th2, IFN-<jats:italic>\u03b1<\/jats:italic>-producing T cells, Tregs, Bregs, and pDCregs was observed in BE\/achalasia patient versus achalasia group. A low percentage of Th1 subset in BE\/achalasia versus achalasia group was determined. A noticeable increase in tissue of Th22, Th17, Th2, Tregs, Bregs, and pDCregs was observed in BE\/achalasia versus achalasia group. Th1 subset was lower in the BE\/achalasia patient versus achalasia group. This study suggests that inflammation is a possible factor in the pathogenesis of BE\/achalasia. Further research needs to be performed to understand the specific cause of the correlation between BE and achalasia.<\/jats:p>","DOI":"10.1155\/2016\/5681590","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T18:02:54Z","timestamp":1474912974000},"page":"1-8","source":"Crossref","is-referenced-by-count":1,"title":["Barrett\u2019s Oesophagus in an Achalasia Patient: Immunological Analysis and Comparison with a Group of Achalasia Patients"],"prefix":"10.1155","volume":"2016","author":[{"given":"Samuel","family":"Torres-Landa","sequence":"first","affiliation":[{"name":"Department of Experimental Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Vasco de Quiroga No. 15, Colonia Belisario Dom\u00ednguez Secci\u00f3n XVI, 14080 Mexico City, 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Gastroenterology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Vasco de Quiroga No. 15, Colonia Belisario Dom\u00ednguez Secci\u00f3n XVI, 14080 Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Alejandro-Medrano","sequence":"additional","affiliation":[{"name":"Department of Experimental Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Vasco de Quiroga No. 15, Colonia Belisario Dom\u00ednguez Secci\u00f3n XVI, 14080 Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"Ramos-\u00c1valos","sequence":"additional","affiliation":[{"name":"Department of Experimental Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Vasco de Quiroga No. 15, Colonia Belisario Dom\u00ednguez Secci\u00f3n XVI, 14080 Mexico City, 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