{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:14:05Z","timestamp":1770448445000,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Science and Technology Project of Zhejiang Province","award":["2013RCB011"],"award-info":[{"award-number":["2013RCB011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>This study aimed to evaluate the clinical efficacy and safety of using the traditional Chinese herbal medicine<jats:italic> Scutellaria baicalensis<\/jats:italic> for the treatment of severe HFMD in 725 patients aged &gt;1 year in a multicenter, retrospective analysis. The patients were divided into the<jats:italic> S. baicalensis<\/jats:italic> and ribavirin groups, and the temperatures, presence or absence of skin rashes and oral lesions, nervous system (NS) involvement, and viral loads of the patients, as well as the safety of the treatments, were evaluated. The median duration of fever, median time to NS involvement, and the number of patients with oral ulcers and\/or vesicles, as well as skin rashes, were decreased in the<jats:italic> S. baicalensis<\/jats:italic> group compared with the ribavirin group. In addition, the EV71 viral loads were decreased in the<jats:italic> S. baicalensis<\/jats:italic> group, suggesting that<jats:italic> S. baicalensis<\/jats:italic> exerted more potent antiviral effects compared with ribavirin. The present study demonstrated that<jats:italic> S. baicalensis<\/jats:italic> was suitable for the treatment of severe HFMD in patients aged &gt;1 year, since it was shown to rapidly relieve fever, attenuate oral lesions and rashes, and improve NS involvement. Furthermore, it was demonstrated to be relatively safe for topical application.<\/jats:p>","DOI":"10.1155\/2016\/5697571","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T17:12:09Z","timestamp":1476983529000},"page":"1-9","source":"Crossref","is-referenced-by-count":22,"title":["Efficacy of<i> Scutellaria baicalensis<\/i> for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis"],"prefix":"10.1155","volume":"2016","author":[{"given":"Hailong","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First People\u2019s Hospital of Yongkang, Jinhua, 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