{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:15:52Z","timestamp":1783181752231,"version":"3.54.6"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"vor","delay-in-days":272,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["CE056149"],"award-info":[{"award-number":["CE056149"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["634424"],"award-info":[{"award-number":["634424"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["APP1010749"],"award-info":[{"award-number":["APP1010749"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["APP1067515"],"award-info":[{"award-number":["APP1067515"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["APP1042368"],"award-info":[{"award-number":["APP1042368"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["09-0084"],"award-info":[{"award-number":["09-0084"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["CE056149"],"award-info":[{"award-number":["CE056149"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["634424"],"award-info":[{"award-number":["634424"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["APP1010749"],"award-info":[{"award-number":["APP1010749"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["APP1067515"],"award-info":[{"award-number":["APP1067515"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["APP1042368"],"award-info":[{"award-number":["APP1042368"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["09-0084"],"award-info":[{"award-number":["09-0084"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["CE056149"],"award-info":[{"award-number":["CE056149"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["634424"],"award-info":[{"award-number":["634424"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["APP1010749"],"award-info":[{"award-number":["APP1010749"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["APP1067515"],"award-info":[{"award-number":["APP1067515"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["APP1042368"],"award-info":[{"award-number":["APP1042368"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["09-0084"],"award-info":[{"award-number":["09-0084"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["CE056149"],"award-info":[{"award-number":["CE056149"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["634424"],"award-info":[{"award-number":["634424"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["APP1010749"],"award-info":[{"award-number":["APP1010749"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["APP1067515"],"award-info":[{"award-number":["APP1067515"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["APP1042368"],"award-info":[{"award-number":["APP1042368"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["09-0084"],"award-info":[{"award-number":["09-0084"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Health and Medical Research Council Project","award":["CE056149"],"award-info":[{"award-number":["CE056149"]}]},{"name":"National Health and Medical Research Council Project","award":["634424"],"award-info":[{"award-number":["634424"]}]},{"name":"National Health and Medical Research Council Project","award":["APP1010749"],"award-info":[{"award-number":["APP1010749"]}]},{"name":"National Health and Medical Research Council Project","award":["APP1067515"],"award-info":[{"award-number":["APP1067515"]}]},{"name":"National Health and Medical Research Council Project","award":["APP1042368"],"award-info":[{"award-number":["APP1042368"]}]},{"name":"National Health and Medical Research Council Project","award":["09-0084"],"award-info":[{"award-number":["09-0084"]}]},{"DOI":"10.13039\/501100000391","name":"Association for International Cancer Research","doi-asserted-by":"publisher","award":["CE056149"],"award-info":[{"award-number":["CE056149"]}],"id":[{"id":"10.13039\/501100000391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000391","name":"Association for International Cancer Research","doi-asserted-by":"publisher","award":["634424"],"award-info":[{"award-number":["634424"]}],"id":[{"id":"10.13039\/501100000391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000391","name":"Association for International Cancer Research","doi-asserted-by":"publisher","award":["APP1010749"],"award-info":[{"award-number":["APP1010749"]}],"id":[{"id":"10.13039\/501100000391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000391","name":"Association for International Cancer Research","doi-asserted-by":"publisher","award":["APP1067515"],"award-info":[{"award-number":["APP1067515"]}],"id":[{"id":"10.13039\/501100000391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000391","name":"Association for International Cancer Research","doi-asserted-by":"publisher","award":["APP1042368"],"award-info":[{"award-number":["APP1042368"]}],"id":[{"id":"10.13039\/501100000391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000391","name":"Association for International Cancer Research","doi-asserted-by":"publisher","award":["09-0084"],"award-info":[{"award-number":["09-0084"]}],"id":[{"id":"10.13039\/501100000391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Liver progenitor cells (LPCs) can proliferate extensively, are able to differentiate into hepatocytes and cholangiocytes, and contribute to liver regeneration. The presence of LPCs, however, often accompanies liver disease and hepatocellular carcinoma (HCC), indicating that they may be a cancer stem cell. Understanding LPC biology and establishing a sensitive, rapid, and reliable method to detect their presence in the liver will assist diagnosis and facilitate monitoring of treatment outcomes in patients with liver pathologies. A transcriptomic meta\u2010analysis of over 400 microarrays was undertaken to compare LPC lines against datasets of muscle and embryonic stem cell lines, embryonic and developed liver (DL), and HCC. Three gene clusters distinguishing LPCs from other liver cell types were identified. Pathways overrepresented in these clusters denote the proliferative nature of LPCs and their association with HCC. Our analysis also revealed 26 novel markers, LPC markers, including <jats:italic>Mcm2<\/jats:italic> and <jats:italic>Ltbp3<\/jats:italic>, and eight known LPC markers, including <jats:italic>M2pk<\/jats:italic> and <jats:italic>Ncam<\/jats:italic>. These markers specified the presence of LPCs in pathological liver tissue by qPCR and correlated with LPC abundance determined using immunohistochemistry. These results showcase the value of global transcript profiling to identify pathways and markers that may be used to detect LPCs in injured or diseased liver.<\/jats:p>","DOI":"10.1155\/2016\/5702873","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T22:00:23Z","timestamp":1475186423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Transcriptomic Signature of Mouse Liver Progenitor Cells"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3212-6938","authenticated-orcid":false,"given":"Adam M.","family":"Passman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7032-2756","authenticated-orcid":false,"given":"Roslyn","family":"London","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-5892","authenticated-orcid":false,"given":"Janina E. E.","family":"Tirnitz-Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Miyajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Strick-Marchand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen J.","family":"Darlington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9628-5842","authenticated-orcid":false,"given":"Megan","family":"Finch-Edmondson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Ochsner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Whelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard A.","family":"Callus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4740-4702","authenticated-orcid":false,"given":"George C. T.","family":"Yeoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,29]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1734199100"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250213"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1084952102001258"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)65299-6"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22704"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.09.039"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02126.x"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.12.004"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1377"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815557"},{"key":"e_1_2_10_11_2","first-page":"813","article-title":"Enhancement of DL-ethionine-induced liver carcinogenesis in rats fed a choline-devoid diet","volume":"61","author":"Shinozuka H.","year":"1978","journal-title":"Journal of the National Cancer Institute"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.022020"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2667"},{"key":"e_1_2_10_14_2","first-page":"418","article-title":"Studies on the proliferation and fate of oval cells in the liver of rats treated with 2-acetylaminofluorene and partial hepatectomy","volume":"114","author":"Tatematsu M.","year":"1984","journal-title":"The American Journal of Pathology"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.3727\/000000005783983278"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)65574-5"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.08.024"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27078"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.08.004"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.07.003"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.06.003"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.031369"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0270-9139(02)00085-x"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01572"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.06.008"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03043"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9070"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.05.030"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911427107"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912203107"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.10.039"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.060"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81683-9"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401092101"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.3.435"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.2144\/04372TE01"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-2607(02)00009-3"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2002-3-7-research0034"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-5-p3"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1089\/153623103322452378"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20311"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21175"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.064477"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061603"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0101"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-07-0172"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.15"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209394"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24559"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.02.006"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2005.05.001"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21973"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.04.013"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-07-6691"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208196"},{"key":"e_1_2_10_57_2","first-page":"1077","article-title":"Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas","volume":"24","author":"Ishizaki Y.","year":"2004","journal-title":"International Journal of Oncology"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.11.002"},{"key":"e_1_2_10_59_2","first-page":"3783","article-title":"Stem cell recruitment and liver de-differentiation in MMTV-neu (ErbB-2) transgenic mice","volume":"23","author":"Freitas I.","year":"2003","journal-title":"Anticancer Research"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1580"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1934"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2694"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.14.5126"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells1041261"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1295405"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.089219"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2003.00454.x"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20088"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.78"},{"key":"e_1_2_10_70_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.22.2731"},{"key":"e_1_2_10_71_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-106302"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m109.012484"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24868"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22597"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.049"},{"key":"e_1_2_10_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02151.x"},{"key":"e_1_2_10_77_2","doi-asserted-by":"crossref","unstructured":"BehnkeM. K. Growth gone awry: exploring the role of embryonic liver development genes in HCV induced cirrhosis and hepatocellular carcinoma [Ph.D. thesis] 2012.","DOI":"10.3390\/cancers4030945"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2029411"},{"key":"e_1_2_10_79_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.26751"}],"container-title":["Stem Cells International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2016\/5702873.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2016\/5702873.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/5702873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T02:27:59Z","timestamp":1722911279000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/5702873"}},"subtitle":[],"editor":[{"given":"James","family":"Adjaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/5702873"],"URL":"https:\/\/doi.org\/10.1155\/2016\/5702873","archive":["Portico"],"relation":{},"ISSN":["1687-966X","1687-9678"],"issn-type":[{"value":"1687-966X","type":"print"},{"value":"1687-9678","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2016-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5702873"}}