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The study was aimed at evaluating the DNA damage response in H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010treated lymphocytes using the alkaline comet assay in bladder cancer (BC) patients as compared to clinically healthy controls, elderly persons, and individuals with chronic inflammations. Polymorphism in DNA repair genes involved in nucleotide excision repair (NER) and base excision repair (BER) was studied using the PCR\u2010RFLP method in the Belarusian population to elucidate the possible association of their variations with both bladder cancer risk and clinicopathological features of tumors. The increased level of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010induced DNA damage and a higher proportion of individuals sensitive to oxidative stress were found among BC patients as compared to other groups under study. Heterozygosity in the <jats:italic>XPD<\/jats:italic> gene (codon 751) increased cancer risk: OR (95% CI) = 1.36 (1.03\u20131.81), <jats:italic>p<\/jats:italic> = 0.031. The frequency of the <jats:italic>XPD<\/jats:italic> 312Asn allele was significantly higher in T \u2265 2 high grade than in T \u2265 2 low grade tumors (<jats:italic>p<\/jats:italic> = 0.036); the <jats:italic>ERCC6<\/jats:italic> 1097Val\/Val genotype was strongly associated with muscle\u2010invasive tumors. Combinations of homozygous wild type alleles occurred with the increased frequency in patients with non\u2010muscle\u2010invasive tumors suggesting that the maintenance of normal DNA repair activity may prevent cancer progression.<\/jats:p>","DOI":"10.1155\/2016\/5710403","type":"journal-article","created":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T21:01:37Z","timestamp":1447707697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Cellular Response to Oxidatively Induced DNA Damage and Polymorphism of Some DNA Repair Genes Associated with Clinicopathological Features of Bladder Cancer"],"prefix":"10.1155","volume":"2016","author":[{"given":"Nataliya V.","family":"Savina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya V.","family":"Nikitchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana D.","family":"Kuzhir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander I.","family":"Rolevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei A.","family":"Krasny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza I.","family":"Goncharova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,16]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00411-009-0258-4"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.01.016"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn075"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geq075"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.20.2973"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03482"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2006.10.011"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2005.04.014"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq193"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv222"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/35077232"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.2"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-5037-5-10"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2011.04.028"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510909103"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2013.02.004"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.6"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2013.03.004"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201205149"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.08.593"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/1354750x.2014.943291"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.03.017"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.01.002"},{"key":"e_1_2_7_24_2","unstructured":"World Medical Association World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects Proceedings of the 18th WMA General Assembly June 1964 Helsinki Finland http:\/\/www.wma.net\/en\/30publications\/10policies\/b3\/index.html."},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2011.05.009"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/1354750x.2011.651157"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2012.06.006"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1098-2280(2000)35:3lt;206::aid-em8>3.0.co;2-j"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(94)90236-4"},{"key":"e_1_2_7_30_2","first-page":"1354","article-title":"Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients","volume":"61","author":"Spitz M. 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