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Female Wistar rats were operated and randomly divided into either sham\u2010operated or OVX groups. Sham\u2010operated group (<jats:italic>n<\/jats:italic> = 8) and one OVX group (<jats:italic>n<\/jats:italic> = 11) were treated with vehicle (refined olive oil), and the other two OVX groups received curcumin at 50 or 100\u2009mg\/Kg\/day doses (<jats:italic>n<\/jats:italic> = 8\/group). OVX vehicle\u2010treated animals presented a higher deposition of intestinal adipose tissue as well as increased serum levels of IL\u20106, LDL, and total cholesterol when compared to sham\u2010operated rats. In addition, several oxidative stress markers in serum, blood, and liver (such as TBARS, carbonyl, reduced\u2010sulphydryl, and nonenzymatic antioxidant defenses) were altered toward a prooxidant status by OVX. Interestingly, curcumin supplementation attenuated most of these parameters to sham comparable values. 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