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Novel approaches using various types of stem cells have been proposed to treat common neurodegenerative disorders such as Alzheimer\u2019s Disease, Parkinson\u2019s Disease, or stroke. Moreover, as the secretome of these cells appears to be of greater benefit compared to the cells themselves, the extracellular components responsible for its therapeutic benefit have been explored. Stem cells, as well as most cells, release extracellular vesicles such as exosomes, which are nanovesicles able to target specific cell types and thus to modify their function by delivering proteins, lipids, and nucleic acids. Exosomes have recently been tested <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> as therapeutic conveyors for the treatment of diseases. As such, they could be engineered to target specific populations of cells within the CNS. Considering the fact that many degenerative brain diseases have an impact on adult neurogenesis, we discuss how the modulation of the adult neurogenic niches may be a therapeutic target of stem cell\u2010derived exosomes. 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