{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T23:12:12Z","timestamp":1773184332051,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK091222"],"award-info":[{"award-number":["DK091222"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK055812"],"award-info":[{"award-number":["DK055812"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK097948"],"award-info":[{"award-number":["DK097948"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK091222"],"award-info":[{"award-number":["DK091222"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK055812"],"award-info":[{"award-number":["DK055812"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK097948"],"award-info":[{"award-number":["DK097948"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001063","name":"Crohn\u2019s and Colitis Foundation of America","doi-asserted-by":"publisher","award":["DK091222"],"award-info":[{"award-number":["DK091222"]}],"id":[{"id":"10.13039\/100001063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001063","name":"Crohn\u2019s and Colitis Foundation of America","doi-asserted-by":"publisher","award":["DK055812"],"award-info":[{"award-number":["DK055812"]}],"id":[{"id":"10.13039\/100001063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001063","name":"Crohn\u2019s and Colitis Foundation of America","doi-asserted-by":"publisher","award":["DK097948"],"award-info":[{"award-number":["DK097948"]}],"id":[{"id":"10.13039\/100001063","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cleveland Digestive Disease Research Core Center","award":["DK091222"],"award-info":[{"award-number":["DK091222"]}]},{"name":"Cleveland Digestive Disease Research Core Center","award":["DK055812"],"award-info":[{"award-number":["DK055812"]}]},{"name":"Cleveland Digestive Disease Research Core Center","award":["DK097948"],"award-info":[{"award-number":["DK097948"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pathogens"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>We report and investigated a case of inadvertent contamination of 125 mice (housed in two germ-free positive-pressurized isolators) with emerging human and coral pathogen<jats:italic>Aspergillus sydowii<\/jats:italic>. The infected mice correspond to genetic line SAMP1\/YitFc, which have 100% immune predisposition to develop Crohn\u2019s disease-like spontaneous pathologies, namely, inflammatory bowel disease (IBD). Pathogen update based on a scoping review of the literature and our clinical observations and experimentation are discussed. The unwanted infection of germ-free mice (immunologically prone to suffer chronic inflammation) with human pathogen<jats:italic>A. sydowii<\/jats:italic>resulted in no overt signs of clinical disease over 3-week exposure period, or during DSS-induced colitis experiments. Results and observations suggest that<jats:italic>A. sydowii<\/jats:italic>alone has limited clinical effect in immunocompromised germ-free mice or that other commensal microbial flora is required for<jats:italic>Aspergillus<\/jats:italic>-associated disease to occur.<\/jats:p>","DOI":"10.1155\/2016\/5748745","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T06:07:15Z","timestamp":1471586835000},"page":"1-7","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Effects of Gamma-Radiation-Resistant<i>Aspergillus sydowii<\/i>on Germ-Free Mice Immunologically Prone to Inflammatory Bowel Disease"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0713-5605","authenticated-orcid":true,"given":"Alexander","family":"Rodriguez-Palacios","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Liver Diseases, Department of Medicine, Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA"},{"name":"Cleveland Digestive Diseases Research Core Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Aladyshkina","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Liver Diseases, Department of Medicine, Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA"},{"name":"Cleveland Digestive Diseases Research Core Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Retuerto","sequence":"additional","affiliation":[{"name":"Center for Medical Mycology, Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Hager","sequence":"additional","affiliation":[{"name":"Center for Medical Mycology, Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3450-2693","authenticated-orcid":true,"given":"Sanja","family":"Ilic","sequence":"additional","affiliation":[{"name":"Department of Human Sciences, Human Nutrition, College of Education and Human Ecology, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud A.","family":"Ghannoum","sequence":"additional","affiliation":[{"name":"Center for Medical Mycology, Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA"},{"name":"Digestive Health Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Cominelli","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Liver Diseases, Department of Medicine, Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA"},{"name":"Cleveland Digestive Diseases Research Core Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA"},{"name":"Digestive Health Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2015.56.5.1453"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.542"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myv067"},{"issue":"6689","key":"4","first-page":"137","volume":"394","year":"1998","journal-title":"Nature"},{"issue":"12","key":"5","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1439-0507.1989.tb02192.x","volume":"32","year":"1989","journal-title":"Mycoses"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2012.667578"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1134\/s0026261713010086"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311657110"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.3630200304"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8577"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.11.028"},{"key":"12","first-page":"315","volume-title":"Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics","year":"1990"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.43.5.2092-2103.2005"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1126\/science.1221789"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2004.12.008"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3354\/dao02106"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1128\/aem.01589-10"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2008.09.013"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1605(94)00129-t"},{"issue":"6","key":"20","first-page":"61","volume":"47","year":"2008","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.04.004"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/jam.12998"}],"container-title":["Journal of Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpath\/2016\/5748745.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpath\/2016\/5748745.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpath\/2016\/5748745.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T22:42:31Z","timestamp":1718750551000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jpath\/2016\/5748745\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":22,"alternative-id":["5748745","5748745"],"URL":"https:\/\/doi.org\/10.1155\/2016\/5748745","relation":{},"ISSN":["2090-3057","2090-3065"],"issn-type":[{"value":"2090-3057","type":"print"},{"value":"2090-3065","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}