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The results showed that the levels of IFN-\u03bb<\/jats:italic>2 were elevated by 17.9% and 14.2% in the plasma of allergic rhinitis (AR) and combined rhinitis with asthma (AR + AS), which was positively correlated with the level of tryptase but negatively correlated with the level of IL-10. IFN-\u03bb<\/jats:italic>2 was predominately expressed in the CD16+ cells and CD14+ cells in healthy control subjects (HC) but upregulated only in CD8+ cells of AR and in eosinophils of asthma. It was observed that approximately 6.6% and 7.0% dispersed tonsil cells and 5.8% and 0.44% dispersed lung cells are IFN-\u03bb<\/jats:italic>2+ mast cells and macrophages. Moreover, tryptase and agonist peptides of PAR-2 induced enhanced IFN-\u03bb<\/jats:italic>2 mRNA expression in A549 cells. In conclusion, the elevated levels of IFN-\u03bb<\/jats:italic>2 in the plasma of AR and AR + AS indicate that IFN-\u03bb<\/jats:italic>2 is likely to contribute to the pathogenesis of allergic airway disorders. The potential origins of the elevated plasma IFN-\u03bb<\/jats:italic>2 include mast cells, macrophages, and epithelial cells in tissues, neutrophils, monocytes, CD8+ T cells, and eosinophils in peripheral blood. Development of IFN-\u03bb<\/jats:italic>2 related therapy may help to treat or prevent allergic airway disorders.<\/jats:p>","DOI":"10.1155\/2016\/5759496","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T21:01:20Z","timestamp":1452546080000},"page":"1-13","source":"Crossref","is-referenced-by-count":3,"title":["Altered Expression of IFN-\u03bb<\/i>2 in Allergic Airway Disorders and Identification of Its Cell Origins"],"prefix":"10.1155","volume":"2016","author":[{"given":"Qiuli","family":"Wang","sequence":"first","affiliation":[{"name":"Department of ENT, Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of ENT, Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Liaoning Medical 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