{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:26:13Z","timestamp":1783164373251,"version":"3.54.6"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pathogens"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>This is the first confirmed report of<jats:italic>Encephalitozoon cuniculi<\/jats:italic>(<jats:italic>E. cuniculi<\/jats:italic>) in farm meat rabbits located in Northern Mexico. Eighty young rabbits exhibited clinical signs of this zoonotic emerging disease, like torticollis, ataxia, paresis, circling, and rolling. Samples of brain, kidney, and liver were examined for histology lesions. For the first time the lesions caused by<jats:italic>E. cuniculi<\/jats:italic>were graded according to their severity (I, II, and III) and the size of the granulomas (Types A, B, and C). The main cerebral injuries were Grade III, coinciding with the presence of Type C granulomas. The cerebral lesions were located in the cortex, brain stem, and medulla. The renal lesions were also Grade III distributed throughout cortex and renal medulla, with no granuloma formation. The involvement of hypersensitivity Types III and IV is suggested. All of the rabbits were seropositive to<jats:italic>E. cuniculi<\/jats:italic>by CIA testing, suggesting that this zoonotic and emerging pathogen is widely distributed among animals intended for human consumption. We believe this work could be used as a guide when examining<jats:italic>E. cuniculi<\/jats:italic>and will provide direction to confirm the diagnosis of this pathogen.<\/jats:p>","DOI":"10.1155\/2016\/5768428","type":"journal-article","created":{"date-parts":[[2016,2,28]],"date-time":"2016-02-28T21:01:04Z","timestamp":1456693264000},"page":"1-9","source":"Crossref","is-referenced-by-count":20,"title":["<i>Encephalitozoon cuniculi<\/i>: Grading the Histological Lesions in Brain, Kidney, and Liver during Primoinfection Outbreak in Rabbits"],"prefix":"10.1155","volume":"2016","author":[{"given":"Luis E.","family":"Rodr\u00edguez-Tovar","sequence":"first","affiliation":[{"name":"Cuerpo Acad\u00e9mico de Zoonosis y Enfermedades Emergentes, Facultad de Medicina Veterinaria y Zootecnia, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Calle Francisco Villa s\/n, Ex-Hacienda El Canad\u00e1, 66050 Escobedo, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia 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