{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T22:47:19Z","timestamp":1777070839404,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T00:00:00Z","timestamp":1449532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007469","name":"Higher Education Research Promotion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007469","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research University Project of Thailand"},{"DOI":"10.13039\/100012527","name":"Office of the Higher Education Commission","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012527","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Due to the crucial role of oxidative stress in the stress\u2010induced memory deficit, the benefit of substance possessing antioxidant effect is focused. Since no data are available, we aimed to determine the effect of <jats:italic>Nelumbo nucifera<\/jats:italic> flowers extract on spatial memory and hippocampal damage in stressed rats. Male Wistar rats, weighing 250\u2013350\u2009g, were orally given <jats:italic>N. nucifera<\/jats:italic> extract at doses of 10, 10, and 200\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup> 45 minutes before the exposure to 12\u2010hour restraint stress. The spatial memory and serum corticosterone were assessed at 7 and 14 days of study period. At the end of study, acetylcholinesterase (AChE), monoamine oxidase type A and monoamine oxidase type B (MAO\u2010A and MAO\u2010B), oxidative stress status, neuron density, and Ki67 expression in hippocampus were also assessed. The results showed that <jats:italic>N. nucifera<\/jats:italic> extract decreased memory deficit and brain damage, serum corticosterone, oxidative stress status, AChE, and MAO\u2010A and MAO\u2010B activities but increased neuron density and Ki67 expression in hippocampus. These suggested that the improved oxidative stress status, adult neurogenesis, and cholinergic and monoaminergic functions might be responsible for the protective effect against stress\u2010related brain damage and dysfunction of the extract. Therefore, <jats:italic>N. nucifera<\/jats:italic> extract is the potential neuroprotective and memory enhancing agent. However, further researches are still required.<\/jats:p>","DOI":"10.1155\/2016\/5789857","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T11:54:49Z","timestamp":1449662089000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Positive Modulation of Pink <i>Nelumbo nucifera<\/i> Flowers on Memory Impairment, Brain Damage, and  Biochemical Profiles in Restraint Rats"],"prefix":"10.1155","volume":"2016","author":[{"given":"Thawatchai","family":"Prabsattroo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7383-2348","authenticated-orcid":false,"given":"Jintanaporn","family":"Wattanathorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pichet","family":"Somsapt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Opass","family":"Sritragool","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,8]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.3109\/10253891003667862"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.09.009"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.22.1.105"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322009001200012"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.08.065"},{"key":"e_1_2_9_6_2","first-page":"548","article-title":"Restraint stress-induced central monoaminergic & oxidative changes in rats & their prevention by novel Ocimum sanctum compounds","volume":"135","author":"Ahmad A.","year":"2012","journal-title":"The Indian Journal of Medical Research"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2006.0207"},{"key":"e_1_2_9_8_2","first-page":"70","article-title":"Antioxidative activity of the leaf of Nelumbo nucifera Gaertn. on oxidative stress-induced erythrocyte hemolysis in hypertensive and normotensive rats","volume":"20","author":"Saengkhae C.","year":"2007","journal-title":"Thai Journal of Physiological Sciences"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1984-82502010000300023"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90830-w"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.9911"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63504-5"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(55)02300-8"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4073.588"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90342-1"},{"key":"e_1_2_9_18_2","volume-title":"Nitric Oxide Protocols","author":"Titheradge M. 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