{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:13:34Z","timestamp":1767168814260,"version":"build-2238731810"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,22]],"date-time":"2015-11-22T00:00:00Z","timestamp":1448150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HL090646-01"],"award-info":[{"award-number":["1R01HL090646-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01HL094467-02"],"award-info":[{"award-number":["5R01HL094467-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HL090646-01"],"award-info":[{"award-number":["1R01HL090646-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01HL094467-02"],"award-info":[{"award-number":["5R01HL094467-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    We hypothesized that fibroblast growth factor\u20109 (FGF\u20109) would enhance angiogenesis via activating c\u2010kit positive stem cells in the infarcted nondiabetic and diabetic heart. In brief, animals were divided into three groups: Sham, MI, and MI+FGF\u20109. Two weeks following MI or sham surgery, our data suggest that treatment with FGF\u20109 significantly diminished vascular apoptosis compared to the MI group in both C57BL\/6 and db\/db mice (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Additionally, the number of c\u2010kit\n                    <jats:sup>+ve<\/jats:sup>\n                    \/SM\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010actin\n                    <jats:sup>+ve<\/jats:sup>\n                    cells and c\u2010kit\n                    <jats:sup>+ve<\/jats:sup>\n                    \/CD31\n                    <jats:sup>+ve<\/jats:sup>\n                    cells were greatly enhanced in the MI+FGF\u20109 groups relative to the MI suggesting FGF\u20109 enhances c\u2010Kit cell activation and their differentiation into vascular smooth muscle cells and endothelial cells, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Histology shows that the total number of vessels were quantified for all groups and our data suggest that the FGF\u20109 treated groups had significantly more vessels than their MI counterparts (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Finally, echocardiographic data suggests a significant improvement in left ventricular output, as indicated by fractional shortening and ejection fraction in both nondiabetic and diabetic animals treated with FGF\u20109 (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Overall, our data suggests FGF\u20109 has the potential to attenuate vascular cell apoptosis, activate c\u2010Kit progenitor cells, and enhance angiogenesis and neovascularization in C57BL\/6 and db\/db mice leading to improved cardiac function.\n                  <\/jats:p>","DOI":"10.1155\/2016\/5810908","type":"journal-article","created":{"date-parts":[[2015,11,22]],"date-time":"2015-11-22T16:01:32Z","timestamp":1448208092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Fibroblast Growth Factor\u20109 Activates c\u2010Kit Progenitor Cells and Enhances Angiogenesis in the Infarcted Diabetic Heart"],"prefix":"10.1155","volume":"2016","author":[{"given":"Dinender","family":"Singla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,22]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.114.303090"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2005.07.004"},{"key":"e_1_2_7_3_2","first-page":"374","article-title":"Clinical characteristics and outcome of diabetic patients with acute myocardial infarction. 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