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Intrauterine hypoxia is a common cause of fetal growth and lung development restriction. Although N-methyl-D-aspartate receptors (NMDARs) are distributed in the postnatal lung and play a role in lung injury, little is known about NMDAR\u2019s expression and role in fetal lung development.<jats:italic>Methods<\/jats:italic>. Real-time PCR and western blotting analysis were performed to detect NMDARs between embryonic days (E) 15.5 and E21.5 in fetal rat lungs. NMDAR antagonist MK-801\u2019s influence on intrauterine hypoxia-induced retardation of fetal lung development was tested<jats:italic>in vivo<\/jats:italic>, and NMDA\u2019s direct effect on fetal lung development was observed using fetal lung organ culture<jats:italic>in vitro<\/jats:italic>.<jats:italic>Results<\/jats:italic>. All seven NMDARs are expressed in fetal rat lungs. Intrauterine hypoxia upregulated NMDARs expression in fetal lungs and decreased fetal body weight, lung weight, lung-weight-to-body-weight ratio, and radial alveolar count, whereas MK-801 alleviated this damage<jats:italic>in vivo<\/jats:italic>.<jats:italic>In vitro<\/jats:italic>experiments showed that NMDA decreased saccular circumference and area per unit and downregulated thyroid transcription factor-1 and surfactant protein-C mRNA expression.<jats:italic>Conclusions<\/jats:italic>. The excessive activation of NMDARs contributed to hypoxia-induced fetal lung development retardation and appropriate blockade of NMDAR might be a novel therapeutic strategy for minimizing the negative outcomes of prenatal hypoxia on lung development.<\/jats:p>","DOI":"10.1155\/2016\/5843981","type":"journal-article","created":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T21:00:27Z","timestamp":1468184427000},"page":"1-11","source":"Crossref","is-referenced-by-count":7,"title":["N-Methyl-D-aspartate Receptor Excessive Activation Inhibited Fetal Rat Lung Development<i>In Vivo<\/i>and<i>In Vitro<\/i>"],"prefix":"10.1155","volume":"2016","author":[{"given":"Zhengchang","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaocheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of 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