{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T21:23:24Z","timestamp":1772227404233,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T00:00:00Z","timestamp":1468281600000},"content-version":"vor","delay-in-days":193,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573072"],"award-info":[{"award-number":["81573072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301384"],"award-info":[{"award-number":["81301384"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. We explored the effects of soy oligopeptides (SOP) in ultraviolet B\u2010 (UVB\u2010) induced acute photodamage of human skin <jats:italic>in vivo<\/jats:italic> and foreskin <jats:italic>ex vivo<\/jats:italic>. <jats:italic>Methods<\/jats:italic>. We irradiated the forearm with 1.5 minimal erythemal dose (MED) of UVB for 3 consecutive days, establishing acute photodamage of skin, and topically applied SOP. Erythema index (EI), melanin index, stratum corneum hydration, and transepidermal water loss were measured by using Multiprobe Adapter 9 device. We irradiated foreskin <jats:italic>ex vivo<\/jats:italic> with the same dose of UVB (180\u2009mJ\/cm<jats:sup>2<\/jats:sup>) for 3 consecutive days and topically applied SOP. Sunburn cells were detected by using hematoxylin and eosin staining. Apoptotic cells were detected by using terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Cyclobutane pyrimidine dimers (CPDs), p53 protein, Bax protein, and Bcl\u20102 protein were detected by using immunohistochemical staining. <jats:italic>Results<\/jats:italic>. Compared with UVB group, UVB\u2010irradiated skin with topically applied SOP showed significantly decreased EI. Compared with UVB group, topical SOP significantly increased Bcl\u20102 protein expression and decreased CPDs\u2010positive cells, sunburn cells, apoptotic cells, p53 protein expression, and Bax protein expressions in the epidermis of UVB\u2010irradiated foreskin. <jats:italic>Conclusion<\/jats:italic>. Our study demonstrated that topical SOP can protect human skin against UVB\u2010induced photodamage.<\/jats:p>","DOI":"10.1155\/2016\/5846865","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T21:26:27Z","timestamp":1468358787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["[Retracted] Protective Effects of Soy Oligopeptides in Ultraviolet B\u2010Induced Acute Photodamage of Human Skin"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7965-7624","authenticated-orcid":false,"given":"Bing-rong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-wen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-an","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia","family":"Permatasari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6074-1298","authenticated-orcid":false,"given":"Dan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,12]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1024112231953"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1011-1344(01)00206-8"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2001.140204.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.09.001"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m011643200"},{"key":"e_1_2_8_6_2","first-page":"129","article-title":"Effects of \u03b1-santalol on proapoptotic caspases and p53 expression in UVB irradiated mouse skin","volume":"28","author":"Arasada B. 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