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However, the molecular mechanism(s) underlying its beneficial effects remains poorly understood. Oxidative stress is known to play a key role in the pathogenesis of diabetic cardiomyopathy and one of the enzyme systems that produce reactive oxygen species is NADH\/NADPH oxidase. The goal of this study was to investigate the effect of streptozotocin\u2010 (STZ\u2010) induced diabetes on expression of p47<jats:sup>phox<\/jats:sup> and p67<jats:sup>phox<\/jats:sup>, key regulatory subunits of NADPH oxidase, in cardiac tissues and determine whether ExT can attenuate these changes. Four weeks after STZ treatment, expression of p47<jats:sup>phox<\/jats:sup> and p67<jats:sup>phox<\/jats:sup> increased 2.3\u2010fold and 1.6\u2010fold, respectively, in left ventricles of diabetic rats and these increases were attenuated with three weeks of ExT, initiated 1 week after onset of diabetes. In atrial tissues, there was increased expression of p47<jats:sup>phox<\/jats:sup> (74%), which was decreased by ExT in diabetic rats. Furthermore, increased collagen III levels in diabetic hearts (52%) were significantly reduced by ExT. Taken together, ExT attenuates the increased expression of p47<jats:sup>phox<\/jats:sup> and p67<jats:sup>phox<\/jats:sup> in the hearts of diabetic rats which could be an underlying mechanism for improving intracardiac matrix and thus cardiac function and prevent cardiac remodeling in diabetic cardiomyopathy.<\/jats:p>","DOI":"10.1155\/2016\/5868913","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T21:02:20Z","timestamp":1455656540000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Exercise Training Attenuates Upregulation of p47<sup>phox<\/sup> and p67<sup>phox<\/sup> in Hearts of Diabetic Rats"],"prefix":"10.1155","volume":"2016","author":[{"given":"Neeru 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