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Eleven SNPs of the<jats:italic>JAK1<\/jats:italic>,<jats:italic>JAK2<\/jats:italic>,<jats:italic>STAT1<\/jats:italic>,<jats:italic>IRF1<\/jats:italic>, and<jats:italic>NOS2<\/jats:italic>genes were analyzed in 443 AAU patients with AS, 486 AAU patients without AS, and 714 healthy controls. Genotyping was performed by PCR-RFLP assay or TaqMan\u00ae probe assay. The Chi-squared (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msup><mml:mrow><mml:mi>\u03c7<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">2<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>) test and multivariate logistic regression analysis were used to compare the distributions of alleles and genotypes between patients and controls.<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>values were adjusted using Bonferroni correction.<jats:italic>Results<\/jats:italic>. We did not observe significant differences in the genotype and allele frequencies of any SNP between AAU patients with or without AS and healthy controls. Stratification analyses by gender and HLA-B27 status showed a boundary significant association between two SNPs (rs10975003 and rs10758669) in<jats:italic>JAK2<\/jats:italic>and AAU (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><mml:mn fontstyle=\"italic\">2<\/mml:mn><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.053<\/mml:mn><\/mml:math>, resp.).<jats:italic>Conclusions<\/jats:italic>. Our results indicated that genetic polymorphisms of the JAK-STAT signaling pathway genes may not be associated with AAU in the Han Chinese population.<\/jats:p>","DOI":"10.1155\/2016\/5896906","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T21:03:40Z","timestamp":1479157420000},"page":"1-9","source":"Crossref","is-referenced-by-count":3,"title":["Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5340-0495","authenticated-orcid":true,"given":"Ling","family":"Cheng","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, 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